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| Description
| - Aims and background: Liver metastases in patients with sarcoma are rare and associated with a poor prognosis. The experience with liver-directed therapies, eg hepatic arterial infusion, in these patients is limited. Methods: Six patients with sarcoma metastatic to the liver (4 patients with gastrointestinal stromal tumors and 2 patients with leiomyosarcoma) were treated by hepatic arterial infusion in our center over a 12-year period. Since the experience was limited, a pooled analysis of reports with data on survival of 22 individual patients was performed. Results: None of the 5 assessable patients responded to the therapy, and liver metastases progressed in all patients. The median survival was 20 months. In the pooled analysis, partial response was observed in 10 of 21 assessable patients (48%) and median survival was 20 months. The survival was significantly longer in responding patients compared to nonresponders (35 vs 14 months; logrank test, P = 0.009). Conclusions: Hepatic arterial infusion
- Aims and background: Liver metastases in patients with sarcoma are rare and associated with a poor prognosis. The experience with liver-directed therapies, eg hepatic arterial infusion, in these patients is limited. Methods: Six patients with sarcoma metastatic to the liver (4 patients with gastrointestinal stromal tumors and 2 patients with leiomyosarcoma) were treated by hepatic arterial infusion in our center over a 12-year period. Since the experience was limited, a pooled analysis of reports with data on survival of 22 individual patients was performed. Results: None of the 5 assessable patients responded to the therapy, and liver metastases progressed in all patients. The median survival was 20 months. In the pooled analysis, partial response was observed in 10 of 21 assessable patients (48%) and median survival was 20 months. The survival was significantly longer in responding patients compared to nonresponders (35 vs 14 months; logrank test, P = 0.009). Conclusions: Hepatic arterial infusion (en)
- Úvod a cíle: jaterní metastázy u pacientů se sarkomem jsou vzácné a spojené se špatnou prognózou. Zkušenosti s terapií směřovanou na játra (hepatická arteriální infuze) jsou omezené. Metody: šest pacientů se sarkomem metastazujícím do jater (4 s gastrointestinálními stromálními nádory a 2 s leiomyosarkomy) byli léčeni hepatickou arteriální infuzí během 12 let. Z důvodu limitovaných zkušeností byla provedená souhrnná analýza zpráv o přežívání 22 pacientů z literatury. Závěry: hepatická arteriální infuze je v léčbě jaterních metastáz u pacientů se sarkomem velmi málo účinná. Daleko slibnější se zdá být chemoembolizace. Přežívání na léčbu reagujících pacientů se zdá být lepší než těch, kteří nereagují (cs)
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| Title
| - Hepatic arterial infusion chemotherapy in sarcoma liver metastases: a report of 6 cases
- Hepatic arterial infusion chemotherapy in sarcoma liver metastases: a report of 6 cases (en)
- Jaterní arteriální chemoterapie u jaterních metastáz sarkomu - popis 6 případů (cs)
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| skos:prefLabel
| - Hepatic arterial infusion chemotherapy in sarcoma liver metastases: a report of 6 cases
- Hepatic arterial infusion chemotherapy in sarcoma liver metastases: a report of 6 cases (en)
- Jaterní arteriální chemoterapie u jaterních metastáz sarkomu - popis 6 případů (cs)
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| skos:notation
| - RIV/00216208:11120/05:00001009!RIV09-MSM-11120___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/05:00001009
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - gastrointestinal stromal tumor; hepatic arterial infusion; leiomyosarcoma; liver metastases (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Krajina, A.
- Filip, S.
- Melichar, B.
- Vobořil, René
- Nožička, J.
- Mergancová, J.
- Jandík, P.
- Cerman, J.-Jr
- Melicharová, K.
- Vobořil, Z.
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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