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  • We have recently developed a simple method of plasma free DNA detection, which enables us to distinguish between apoptotic and genomic (necrotic) DNA. After applying this method to the critically ill, we revealed apoptotic DNA on the day of admission to be higher than later when multiple-organ failure developed. Moreover, apoptotic DNA contributed to total plasma DNA much more than DNA from necrotic cells and its increase predicted future development of multiple-organ failure and death.
  • We have recently developed a simple method of plasma free DNA detection, which enables us to distinguish between apoptotic and genomic (necrotic) DNA. After applying this method to the critically ill, we revealed apoptotic DNA on the day of admission to be higher than later when multiple-organ failure developed. Moreover, apoptotic DNA contributed to total plasma DNA much more than DNA from necrotic cells and its increase predicted future development of multiple-organ failure and death. (en)
  • Nedávno jsme vyvinuli jednoduchou metodu detekce plasmatické DNA, která umožní rozlišit DNA z nekrotických a apoptotických buněk. Při aplikaci této metody na smíšenou populaci kriticky nemocných jsme zjistili, že vyšší hladiny apoptotické DNA 1. den po příjmu mají nemocní, u kterých se později rozvine multiorgánové selhávání. Navíc, apoptotická DNA převažovala nad DNA z nekrotických buněk u nepřeživších. (cs)
Title
  • Apoptosis as an early event in the development of multiple organ failure?
  • Apoptosis as an early event in the development of multiple organ failure? (en)
  • Apoptóza jako časná událost při rozvoji multiorgánového selhávání? (cs)
skos:prefLabel
  • Apoptosis as an early event in the development of multiple organ failure?
  • Apoptosis as an early event in the development of multiple organ failure? (en)
  • Apoptóza jako časná událost při rozvoji multiorgánového selhávání? (cs)
skos:notation
  • RIV/00216208:11120/05:00001004!RIV09-MSM-11120___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 512739
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11120/05:00001004
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • multiple-organ failure; early apoptosis; apoptic DNA; plasma free DNA (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [A91230829340]
http://linked.open...i/riv/nazevZdroje
  • Physiological Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 54
http://linked.open...iv/tvurceVysledku
  • Duška, František
  • Waldauf, P.
  • Pachl, Jan
  • Fric, M.
  • Fanta, Jan
  • Žďárský, Emanuel
http://linked.open...ain/vavai/riv/wos
  • 000234481000017
issn
  • 0862-8408
number of pages
http://localhost/t...ganizacniJednotka
  • 11120
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