About: Iosimenol, a low-viscosity nonionic dimer - Preclinical physicochemistry, pharmacology, and pharmacokinetics     Goto   Sponge   NotDistinct   Permalink

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Description
  • Newer radiologic techniques require fast bolus injections and thus low-viscosity, high-concentration, well-tolerated contrast media (CM), especially in vulnerable patients. To this end, we designed and developed iosimenol, a novel isotonic nonionic dimer, and have conducted tests to enable its clinical evaluation. Standard physicochemical methods were used. Effects on erythrocyte morphology and coagulation were investigated in human and rat blood. Neural tolerance was assessed by behavioral tests in rats after intracisternal injection. Immunosensitizing potential was evaluated by the skin sensitization test in guinea pigs and by the popliteal lymph node assay in rats. Pharmacokinetics and biotransformation were investigated in rats and dogs. Iosimenol is extremely hydrophilic, it is less viscous than any other isotonic CM, has little effect on erythrocytes and blood coagulation, and has good neural tolerance. No immunosensitizing effect was found in validated animal models. Pharmacokinetics are identi
  • Newer radiologic techniques require fast bolus injections and thus low-viscosity, high-concentration, well-tolerated contrast media (CM), especially in vulnerable patients. To this end, we designed and developed iosimenol, a novel isotonic nonionic dimer, and have conducted tests to enable its clinical evaluation. Standard physicochemical methods were used. Effects on erythrocyte morphology and coagulation were investigated in human and rat blood. Neural tolerance was assessed by behavioral tests in rats after intracisternal injection. Immunosensitizing potential was evaluated by the skin sensitization test in guinea pigs and by the popliteal lymph node assay in rats. Pharmacokinetics and biotransformation were investigated in rats and dogs. Iosimenol is extremely hydrophilic, it is less viscous than any other isotonic CM, has little effect on erythrocytes and blood coagulation, and has good neural tolerance. No immunosensitizing effect was found in validated animal models. Pharmacokinetics are identi (en)
Title
  • Iosimenol, a low-viscosity nonionic dimer - Preclinical physicochemistry, pharmacology, and pharmacokinetics
  • Iosimenol, a low-viscosity nonionic dimer - Preclinical physicochemistry, pharmacology, and pharmacokinetics (en)
skos:prefLabel
  • Iosimenol, a low-viscosity nonionic dimer - Preclinical physicochemistry, pharmacology, and pharmacokinetics
  • Iosimenol, a low-viscosity nonionic dimer - Preclinical physicochemistry, pharmacology, and pharmacokinetics (en)
skos:notation
  • RIV/00216208:11120/04:00003835!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita
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  • N
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  • 3
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  • 568982
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  • RIV/00216208:11120/04:00003835
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  • iosimenol; nonionic dimer; pharmacokinetics; viscosity; toxicology; x-ray contrast media (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [CCB791EBFA50]
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  • Investigative Radiology
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  • 39
http://linked.open...iv/tvurceVysledku
  • Fišerová, Magdaléna
  • Sovak, M.
http://linked.open...ain/vavai/riv/wos
  • 000189320200006
issn
  • 0020-9996
number of pages
http://bibframe.org/vocab/doi
  • 10.1097/01.rli.0000115332.25954.a3
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  • 11120
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