About: Effect of intravenous corticosteroids on death within 14 days in 10 008 adults with clinically significant head injury: MRC CRASH trial: randomised placebo-controlled trial

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About: Effect of intravenous corticosteroids on death within 14 days in 10 008 adults with clinically significant head injury: MRC CRASH trial: randomised placebo-controlled trial Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdfs:seeAlso	http://dx.doi.org/10.1016/S0140-6736(04)17188-2
Description	Corticosteroids have been used to treat head injuries for more than 30 years. In 1997, findings of a systematic review suggested that these drugs reduce risk of death by 1-2%. The CRASH trial-a multicentre international collaboration-aimed to confirm or refute such an effect by recruiting 20 000 patients. In May, 2004, the data monitoring committee disclosed the unmasked results to the steering committee, which stopped recruitment. Methods 10 008 adults with head injury and a Glasgow coma score (GCS) of 14 or less within 8 h of injury were randomly allocated 48 h infusion of corticosteroids (methylprednisolone) or placebo. Primary outcomes were death within 2 weeks of injury and death or disability at 6 months. Prespecified subgroup analyses were based on injury severity (GCS) at randomisation and on time from injury to randomisation. Analysis was by intention to treat. Effects on outcomes within 2 weeks of randomisation are presented in this report. This study is registered as an International Standa Corticosteroids have been used to treat head injuries for more than 30 years. In 1997, findings of a systematic review suggested that these drugs reduce risk of death by 1-2%. The CRASH trial-a multicentre international collaboration-aimed to confirm or refute such an effect by recruiting 20 000 patients. In May, 2004, the data monitoring committee disclosed the unmasked results to the steering committee, which stopped recruitment. Methods 10 008 adults with head injury and a Glasgow coma score (GCS) of 14 or less within 8 h of injury were randomly allocated 48 h infusion of corticosteroids (methylprednisolone) or placebo. Primary outcomes were death within 2 weeks of injury and death or disability at 6 months. Prespecified subgroup analyses were based on injury severity (GCS) at randomisation and on time from injury to randomisation. Analysis was by intention to treat. Effects on outcomes within 2 weeks of randomisation are presented in this report. This study is registered as an International Standa (en)
Title	Effect of intravenous corticosteroids on death within 14 days in 10 008 adults with clinically significant head injury: MRC CRASH trial: randomised placebo-controlled trial Effect of intravenous corticosteroids on death within 14 days in 10 008 adults with clinically significant head injury: MRC CRASH trial: randomised placebo-controlled trial (en)
skos:prefLabel	Effect of intravenous corticosteroids on death within 14 days in 10 008 adults with clinically significant head injury: MRC CRASH trial: randomised placebo-controlled trial Effect of intravenous corticosteroids on death within 14 days in 10 008 adults with clinically significant head injury: MRC CRASH trial: randomised placebo-controlled trial (en)
skos:notation	RIV/00216208:11120/04:00003026!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	N
http://linked.open...avai/riv/aktivity	N
http://linked.open...iv/cisloPeriodika	9442
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Edelmann, Karel Pachl, J.
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	561932
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/04:00003026
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Spinal-Cord-Injury; Care Management; Practical Scale; Intensive-Care; Brain-Injury; Methylprednisolone (en)
http://linked.open.../riv/klicoveSlovo	Methylprednisolone Brain-Injury Care Management Intensive-Care Practical Scale Spinal-Cord-Injury
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[51023A3489AD]
http://linked.open...i/riv/nazevZdroje	Lancet
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	364
http://linked.open...iv/tvurceVysledku	Edelmann, Karel Pachl, Jan
http://linked.open...ain/vavai/riv/wos	000224349700027
issn	0140-6736
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/S0140-6736(04)17188-2
http://localhost/t...ganizacniJednotka	11120

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