About: The effect of bromide on the ultrastructure of rat thyrocytes

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/S0940-9602(04)80004-9
Description	Electron microscopic examination of thyroid tissue following administration of bromide to rats showed marked hypertrophy and hyperplasia in the thyrocytes, microfollicular rearrangement and lowered volume of colloid. The luminal surface of the thyrocytes showed increased size and number of microvilli, often filling the microlumen. Most of the nuclei were irregular in shape with unusual incisions and a higher density of chromatin. Proliferation of ER was seen with significantly dilated cisterns containing low electron density material. The Golgi complex was well developed and larger in rats receiving 10 mg Br-/l drinking water (16 days) and 100 mg Br-/l (16 and 66 days) than in control rats. Granules and small spherical structures (50-100 nm) appeared in the subapical part of the cytoplasm and their number increased in animals after administration of 50 mg Br-/l (16 and 66 days), 100 mg Br-/l (16 and 66 days), 200 and 400 mg Br-/l (133 days). Electron microscopic examination of thyroid tissue following administration of bromide to rats showed marked hypertrophy and hyperplasia in the thyrocytes, microfollicular rearrangement and lowered volume of colloid. The luminal surface of the thyrocytes showed increased size and number of microvilli, often filling the microlumen. Most of the nuclei were irregular in shape with unusual incisions and a higher density of chromatin. Proliferation of ER was seen with significantly dilated cisterns containing low electron density material. The Golgi complex was well developed and larger in rats receiving 10 mg Br-/l drinking water (16 days) and 100 mg Br-/l (16 and 66 days) than in control rats. Granules and small spherical structures (50-100 nm) appeared in the subapical part of the cytoplasm and their number increased in animals after administration of 50 mg Br-/l (16 and 66 days), 100 mg Br-/l (16 and 66 days), 200 and 400 mg Br-/l (133 days). (en)
Title	The effect of bromide on the ultrastructure of rat thyrocytes The effect of bromide on the ultrastructure of rat thyrocytes (en)
skos:prefLabel	The effect of bromide on the ultrastructure of rat thyrocytes The effect of bromide on the ultrastructure of rat thyrocytes (en)
skos:notation	RIV/00216208:11120/04:00002997!RIV12-GA0-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA304/00/1481), P(GA304/02/0342), P(GA311/94/0810), Z(AV0Z5039906), Z(MSM 111100003)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Titlbach, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	561807
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/04:00002997
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	thyroid gland; thyrocytes; rat; bromide (en)
http://linked.open.../riv/klicoveSlovo	thyroid gland bromide rat thyrocytes
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[2449FF6AA770]
http://linked.open...i/riv/nazevZdroje	Annals of Anatomy
http://linked.open...in/vavai/riv/obor	EA
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Dynamic structure and function in the cell nucleus Functions and molecular interactions of DOA protein kinase in signal transduction during Drosophila development. Effects of Elevated Bromine Concentration on the Intrathyroidal Metabolismus of Iodine and Thyroid Gland Disorders
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	186
http://linked.open...iv/tvurceVysledku	Titlbach, Milan Velický, Jan
http://linked.open...ain/vavai/riv/wos	000222263500003
http://linked.open...n/vavai/riv/zamer	The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111100003
issn	0940-9602
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/S0940-9602(04)80004-9
http://localhost/t...ganizacniJednotka	11120

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