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| rdf:type
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| Description
| - Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine receptor-bearing leukocytes. Chemokines play important roles in leukocyte trafficking and blocking chemokines can effectively reduce renal leukocyte recruitment and subsequent renal damage. However, recent data indicate that blocking chemokine or chemokine receptor activity in renal disease may also exacerbate renal inflammation under certain conditions. An increasing amount of data indicates additional roles of chemokines in the regulation of innate and adaptive immune responses, which may adversively affect the outcome of interventional studies. This review summarizes available in vivo studies on the blockade of chemokines and chemokine receptors in kidney diseases, with a special focus on the therapeutic potential of anti-chemokine strategies, includi
- Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine receptor-bearing leukocytes. Chemokines play important roles in leukocyte trafficking and blocking chemokines can effectively reduce renal leukocyte recruitment and subsequent renal damage. However, recent data indicate that blocking chemokine or chemokine receptor activity in renal disease may also exacerbate renal inflammation under certain conditions. An increasing amount of data indicates additional roles of chemokines in the regulation of innate and adaptive immune responses, which may adversively affect the outcome of interventional studies. This review summarizes available in vivo studies on the blockade of chemokines and chemokine receptors in kidney diseases, with a special focus on the therapeutic potential of anti-chemokine strategies, includi (en)
- Chemokiny v součinnosti s cytokiny a adhezními molekulami hraji různé role v lokální a systémové imunitní odpovědi. V ledvině exprese chemokinů místem a časově odpovídá lokálnímu poškození ledviny a akumulaci leukocytů exprimujících chemokinové receptory. Chemokiny jsou důležité v řízení pohybu lamfocytů v těle a blokáda chemokinů může efektivně snížit infiltraci zánětlivých buněk do intersticia ledviny a následné poškození parenchymu. Tento souhrn popisuje dostupné in vivo studie s blokátory chemokinů a chemokinových receptorů u onemocnění ledvin, s důrazem na možný terapeutický potenciál antichemokinové léčby u onemocnění ledvin, včetně možných nežádoucích účinků této terapie. (cs)
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| Title
| - Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice
- Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice (en)
- Identifikace chemokinů jako cíle terapie u onemocnění ledvin: poučení ze studií používajících knockout myši a antagonisty (cs)
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| skos:prefLabel
| - Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice
- Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice (en)
- Identifikace chemokinů jako cíle terapie u onemocnění ledvin: poučení ze studií používajících knockout myši a antagonisty (cs)
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| skos:notation
| - RIV/00216208:11120/04:00000978!RIV09-MSM-11120___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/04:00000978
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - chemokine; leukocyte recruitment; kidney; inflammation; renal failure; transplantation (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - CH - Švýcarská konfederace
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Kidney & Blood Press Research
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Eis, Václav
- Anders, H. J.
- Schlondorff, D.
- Vielhauer, V.
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| http://linked.open...ain/vavai/riv/wos
| |
| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
| |
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