About: Effect of two different cytoprotectives, ethiofos and -NGF on cisplatin-induced toxicity in Schwann cell cultures: a preliminary study     Goto   Sponge   NotDistinct   Permalink

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Description
  • Pro snížení toxického účinku cisplatiny v buněčných kulturách Schwannových buněk byly použity dvě cytoprotektivní substance - ethiofos (WR2721) a nervový růstový faktor (NGF). Účinek obou sledovaných substancí byl hodnocen pomocí testu mikrojader a comet assay. Cistplatina vyvolávala dávkově závislé poškození DNA v kultivovaných buňkách. Významný protektivní efekt NGF byl zaznamenán v kulturách Schwannových buněk isolovaných ze spinálních ganglií laboratorního potkana. (cs)
  • Two cytoprotective agents, ethiofos (WR2721) and nerve growth factor (NGF), were used to diminish cisplatin-induced toxicity in Schwann cell cultures. The effect of both studied agents was estimated by a micronucleus test and the comet assay. The comet assay was performed in cultured human Schwann cells isolated from sural nerve biopsies, and the micronucleus test was used in primary cultures of Schwann cells isolated from foetal rat dorsal root ganglia (DRG).
  • Two cytoprotective agents, ethiofos (WR2721) and nerve growth factor (NGF), were used to diminish cisplatin-induced toxicity in Schwann cell cultures. The effect of both studied agents was estimated by a micronucleus test and the comet assay. The comet assay was performed in cultured human Schwann cells isolated from sural nerve biopsies, and the micronucleus test was used in primary cultures of Schwann cells isolated from foetal rat dorsal root ganglia (DRG). (en)
Title
  • Efekt dvou různých cytoprotektiv ethiofosu beta-NGF na ovlivnění toxicity navozené cisplatinem v kultivovaných Schwannových buňkách. Předběžná studie (cs)
  • Effect of two different cytoprotectives, ethiofos and -NGF on cisplatin-induced toxicity in Schwann cell cultures: a preliminary study
  • Effect of two different cytoprotectives, ethiofos and -NGF on cisplatin-induced toxicity in Schwann cell cultures: a preliminary study (en)
skos:prefLabel
  • Efekt dvou různých cytoprotektiv ethiofosu beta-NGF na ovlivnění toxicity navozené cisplatinem v kultivovaných Schwannových buňkách. Předběžná studie (cs)
  • Effect of two different cytoprotectives, ethiofos and -NGF on cisplatin-induced toxicity in Schwann cell cultures: a preliminary study
  • Effect of two different cytoprotectives, ethiofos and -NGF on cisplatin-induced toxicity in Schwann cell cultures: a preliminary study (en)
skos:notation
  • RIV/00216208:11120/04:00000977!RIV09-MSM-11120___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 562090
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11120/04:00000977
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • cisplatin; ethiofos; nerve growth factor; Schwarm cells; comet assay; micronucleus test (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [3E81E8627E94]
http://linked.open...i/riv/nazevZdroje
  • Neuroscience Research Communications
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 35
http://linked.open...iv/tvurceVysledku
  • Jirsová, Kateřina
  • Mandys, Václav
  • Bär, P. R.
http://linked.open...ain/vavai/riv/wos
  • 000224899700003
issn
  • 0893-6609
number of pages
http://localhost/t...ganizacniJednotka
  • 11120
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