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| rdf:type
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| Description
| - Cis-diaminechloro-[2-(diethylamino) ethyl 4-amino-benzoate, N-4]-chloride platinum (II) monohydrochloride monohydrate (DPR) is a new platinum triamine complex obtained from the synthesis of cisplatin and procaine. In this paper we analyzed, adopting a disease-oriented strategy, the tumour selectivity of this compound, its ability to induce apoptosis and its mechanism of interaction with DNA. The inhibition of cell proliferation was evaluated by the MTT assay using a panel of 51 tumour cell lines. Some of them were also evaluated for the induction of apoptosis by 4'-6-diamidine-2'-phenylindole (DAPI) staining, Western blot of p53 protein and agarose gel electrophoresis of ladder DNA. Finally, interstand cross-links (ISCL) were evaluated by ethidium bromide fluorescence technique. When evaluated by the MTT assay, DPR showed a high selective activity for neuroblastoma, small cell lung cancer (SCLC), ovarian cancer and leukemia cell lines. The comparison of mean graphs of DPR and cisplatin sugg
- Cis-diaminechloro-[2-(diethylamino) ethyl 4-amino-benzoate, N-4]-chloride platinum (II) monohydrochloride monohydrate (DPR) is a new platinum triamine complex obtained from the synthesis of cisplatin and procaine. In this paper we analyzed, adopting a disease-oriented strategy, the tumour selectivity of this compound, its ability to induce apoptosis and its mechanism of interaction with DNA. The inhibition of cell proliferation was evaluated by the MTT assay using a panel of 51 tumour cell lines. Some of them were also evaluated for the induction of apoptosis by 4'-6-diamidine-2'-phenylindole (DAPI) staining, Western blot of p53 protein and agarose gel electrophoresis of ladder DNA. Finally, interstand cross-links (ISCL) were evaluated by ethidium bromide fluorescence technique. When evaluated by the MTT assay, DPR showed a high selective activity for neuroblastoma, small cell lung cancer (SCLC), ovarian cancer and leukemia cell lines. The comparison of mean graphs of DPR and cisplatin sugg (en)
- Protinádorový účinek nové platinové sloučeniny získané syntézou cisplatiny a prokainu, komplexu cis-diaminechloro-2-diethylamino ethyl 4-amino-benzoát, N 4- chloridu platiny (II) monohydrochlorid monohydrátu, byl sledován v nádorových buňkách kultivovaných in vitro. Získané výsledky prokázaly protinádorové působení nové sloučeniny, která indukovala apoptózu v nádorových buňkách, zejména neuroblastomu a malobuněčného karcinomu. (cs)
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| Title
| - Inhibice růstu buněk, indukce apoptózy a mechanizmus účinku nové platinové sloučeniny cis-diaminechloro-2-diethylamino ethyl 4-amino-benzoát, N 4- chloridu platiny (II) monohydrochlorid monohydrátu (cs)
- Inhibition of cell growth, induction of apoptosis and mechanism of action of the novel platinum compound cis-diaminechloro-[2-(diethylamino) ethyl 4-amino-benzoate, N-4]-chloride platinum (II) monohydrochloride monohydrate
- Inhibition of cell growth, induction of apoptosis and mechanism of action of the novel platinum compound cis-diaminechloro-[2-(diethylamino) ethyl 4-amino-benzoate, N-4]-chloride platinum (II) monohydrochloride monohydrate (en)
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| skos:prefLabel
| - Inhibice růstu buněk, indukce apoptózy a mechanizmus účinku nové platinové sloučeniny cis-diaminechloro-2-diethylamino ethyl 4-amino-benzoát, N 4- chloridu platiny (II) monohydrochlorid monohydrátu (cs)
- Inhibition of cell growth, induction of apoptosis and mechanism of action of the novel platinum compound cis-diaminechloro-[2-(diethylamino) ethyl 4-amino-benzoate, N-4]-chloride platinum (II) monohydrochloride monohydrate
- Inhibition of cell growth, induction of apoptosis and mechanism of action of the novel platinum compound cis-diaminechloro-[2-(diethylamino) ethyl 4-amino-benzoate, N-4]-chloride platinum (II) monohydrochloride monohydrate (en)
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| skos:notation
| - RIV/00216208:11120/04:00000966!RIV09-MSM-11120___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/04:00000966
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - DPR; growth inhibition; apoptosis; cell lines; mechanism of action (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Investigational New Drugs
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Mandys, Václav
- Cafaggi, S.
- Viale, M.
- Mariggio, M.
- Ottone, M.
- Parodi, B.
- Vannozzi, M. O.
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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