About: Behandlung der Gonarthrose. Wirksamkeit und Verträglichkeit von retardiertem Acemetacin im Vergleich zu Celecoxib     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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Description
  • The aim of this trial was to compare acemetacin (ACE) with celecoxib (CEL) in terms of tolerability and efficacy in the treatment of osteoarthritis of the knee joint. A total of 105 patients (2664 years old) suffering from primary osteoarthritis (OA) of the knee were enrolled in this international, multicenter, randomized, double blind controlled trial. Fifty three patients were given ACE and 52 CEL. They were treated with either 90 mg bid of slow release ACE or 200 mg bid of CEL for 6 weeks. Additional gastroprotective therapy was not provided. Tolerability was assessed by physical examination, laboratory tests, vital signs and reports of side effects, as well as by patient and physician global assessments. Efficacy parameters comprised pain assessment by visual analogue scale (VAS) and ordinal scale, WOMAC, SF-36 and patient and physician global impressions of efficacy. In addition,acetaminophen consumption was recorded. Results. In 21 ACE (39.6%) and 19 CEL patients (36.5%), the number of side effe (en)
  • Práce porovnává účinnost a toleranci pomalu působícího acemetacinu s celecoxibem při léčbě osteoartritidy kolenního kloubu (cs)
  • In einer kontrollierten, doppelblinden, randomisierten Multicenter-Studie wurden Wirksamkeit und Verträglichkeit von Acemetacin im Vergleich zu Celecoxib bei der Behandlung von Patienten mit Gonarthrose (mindestens Kellgren 2) untersucht. 105 Patienten im Alter zwischen 26 und 64 Jahren wurden in die Studie eingeschlossen und randomisiert. 53 Partienten erhielten 2x90 mg/d retardiertes Acemetacin (ACE) und 52 Patienten 2x200 mg/d Celecoxib (CEL), Therapiedauer war sechs Wochen. Eine gastroprotektive Zusatzmedikation während der Studie war nicht erlaubt
Title
  • Behandlung der Gonarthrose. Wirksamkeit und Verträglichkeit von retardiertem Acemetacin im Vergleich zu Celecoxib
  • Treatment of osteoarthritis of the knee joint. Efficacy and tolerance to acemetacin slow release in comparison to celecoxib (en)
  • Léčba osteoartritidy kolenního kloubu. Účinnost a tolerance pomalu působícího acemetacinu v porovnání s celecoxibem (cs)
skos:prefLabel
  • Behandlung der Gonarthrose. Wirksamkeit und Verträglichkeit von retardiertem Acemetacin im Vergleich zu Celecoxib
  • Treatment of osteoarthritis of the knee joint. Efficacy and tolerance to acemetacin slow release in comparison to celecoxib (en)
  • Léčba osteoartritidy kolenního kloubu. Účinnost a tolerance pomalu působícího acemetacinu v porovnání s celecoxibem (cs)
skos:notation
  • RIV/00216208:11120/04:00000962!RIV09-MSM-11120___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 9
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 555911
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11120/04:00000962
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • acemetacin; celecoxib; idiopathic osteoarthritis of the knee; clinical trial; WOMAC (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [5C2C7463CE75]
http://linked.open...i/riv/nazevZdroje
  • Orthopäde
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 33
http://linked.open...iv/tvurceVysledku
  • Broll, H.
  • Singer, F.
  • Valešová, Marie
  • Leeb, B. F.
  • Aglas, F.
  • Busci, L.
  • Bőhmová, J.
  • Hawel, R.
  • Keszthelyi, B.
  • Mayrhofer, F.
http://linked.open...ain/vavai/riv/wos
  • 000224079700009
issn
  • 0085-4530
number of pages
http://localhost/t...ganizacniJednotka
  • 11120
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