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| rdf:type
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| Description
| - Práce popisuje, že aktivace tool-like receptoru-9 indukuje progresi renálního onemocnení u MRL-Fas(lpr) myší (cs)
- How bacterial or viral infections trigger flares of autoimmunity is poorly understood. As toll-like receptor (TLR)-9 activation by exogenous or endogenous CpG-DNA may contribute to disease activity of systemic lupus erythematosus, we examined the effects of CpG-oligodeoxynucleotides (ODN) or DNA derived from Escherichia coli (E. coli) on the course of nephritis in MRL1pr/1pr mice. In kidneys of these mice, TLR9 localized to glomerular, tubulointerstitial, and perivascular infiltrates. After intraperitoneal injection labeled CpG-ODN localized to glomerular and interstitial macrophages and dendritic cells in nephritic kidneys of MRL1pr/1pr mice but not in healthy MRL controls. Furthermore, murine J774 macrophages and splenocytes from MRL1pr/1pr mice, but not tubular epithelial cells, renal fibroblasts, or mesangial cells, expressed TLR9 and up-regulated CCL5/RANTES mRNA upon stimulation with CpG-ODN in vitro. In vivo both E. coli DNA and CpG-ODN increased serum DNA autoantibodies of the IgG(2a) isotype
- How bacterial or viral infections trigger flares of autoimmunity is poorly understood. As toll-like receptor (TLR)-9 activation by exogenous or endogenous CpG-DNA may contribute to disease activity of systemic lupus erythematosus, we examined the effects of CpG-oligodeoxynucleotides (ODN) or DNA derived from Escherichia coli (E. coli) on the course of nephritis in MRL1pr/1pr mice. In kidneys of these mice, TLR9 localized to glomerular, tubulointerstitial, and perivascular infiltrates. After intraperitoneal injection labeled CpG-ODN localized to glomerular and interstitial macrophages and dendritic cells in nephritic kidneys of MRL1pr/1pr mice but not in healthy MRL controls. Furthermore, murine J774 macrophages and splenocytes from MRL1pr/1pr mice, but not tubular epithelial cells, renal fibroblasts, or mesangial cells, expressed TLR9 and up-regulated CCL5/RANTES mRNA upon stimulation with CpG-ODN in vitro. In vivo both E. coli DNA and CpG-ODN increased serum DNA autoantibodies of the IgG(2a) isotype (en)
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| Title
| - Aktivace tool-like receptoru-9 indukuje progresi renálního onemocnení u MRL-Fas(lpr) myší (cs)
- Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice
- Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice (en)
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| skos:prefLabel
| - Aktivace tool-like receptoru-9 indukuje progresi renálního onemocnení u MRL-Fas(lpr) myší (cs)
- Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice
- Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice (en)
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| skos:notation
| - RIV/00216208:11120/04:00000952!RIV09-MSM-11120___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/04:00000952
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - systemic-lupus-erythematosus; bacterial Cpg-DNA; immune-complex glomerulonephritis; chemokine receptor; NZB/NZW mice; expression; cells; immunization; autoimmunity; antibodies (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Bauer, S.
- Eis, Václav
- Wagner, H.
- Anders, H. J.
- Schlondorff, D.
- Vielhauer, V.
- Grone, H. J.
- Kretzler, M.
- Linde, Y.
- Perez de Lema, G.
- Rutz, M.
- Strutz, F.
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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