About: Antimutagenic Effect of Resveratrol and Diallylsulphide and its Effect on the Immune Response in Mice

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Using the Ames bacterial mutagenicity test and an in vivo micronucleus test, we investigated the antigenotoxic effect of Resveratrol (RES) and Diallylsulphide (DAS) against the genotoxicity of three mutagens: aminomethylimidazo-quinoline (IQ), aflatoxin B1 (AFB1), and N-nitroso-N-methylurea (MNU). The protective effect of resveratrol and diallyl sulfide was assessed by the chemiluminescence method detecting the production of oxygen radicals, namely the production of the complex of hydrogen peroxide-myeloperoxidase-halid cofactor during phagocytosis, and by the blastic transformation method testing the functional capacity of T-lymphocytes. In all of the experiments resveratrol and diallyl sulfide to a significant degree repaired the immunosuppressive effects of all three carcinogens tested. Resveratrol and diallyl sulfide demonstrably inhibits the mutagenic activity of three reference mutagens. Using the Ames bacterial mutagenicity test and an in vivo micronucleus test, we investigated the antigenotoxic effect of Resveratrol (RES) and Diallylsulphide (DAS) against the genotoxicity of three mutagens: aminomethylimidazo-quinoline (IQ), aflatoxin B1 (AFB1), and N-nitroso-N-methylurea (MNU). The protective effect of resveratrol and diallyl sulfide was assessed by the chemiluminescence method detecting the production of oxygen radicals, namely the production of the complex of hydrogen peroxide-myeloperoxidase-halid cofactor during phagocytosis, and by the blastic transformation method testing the functional capacity of T-lymphocytes. In all of the experiments resveratrol and diallyl sulfide to a significant degree repaired the immunosuppressive effects of all three carcinogens tested. Resveratrol and diallyl sulfide demonstrably inhibits the mutagenic activity of three reference mutagens. (en)
Title	Antimutagenic Effect of Resveratrol and Diallylsulphide and its Effect on the Immune Response in Mice Antimutagenic Effect of Resveratrol and Diallylsulphide and its Effect on the Immune Response in Mice (en)
skos:prefLabel	Antimutagenic Effect of Resveratrol and Diallylsulphide and its Effect on the Immune Response in Mice Antimutagenic Effect of Resveratrol and Diallylsulphide and its Effect on the Immune Response in Mice (en)
skos:notation	RIV/00216208:11120/03:00007362!RIV/2004/MZ0/111204/N
http://linked.open.../vavai/riv/strany	57;58
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NJ7462), Z(MSM 111200001)
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Šmerák, Petr Polívková, Zdeňka Anděl, M. Bártová, Jiřina Bárta, Ivo Langová, Martina
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	598615
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/03:00007362
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Antimutagenic;Effect;Resveratrol;Diallylsulphide;Effect;Immune;Response;Mice (en)
http://linked.open.../riv/klicoveSlovo	Response Mice Resveratrol Diallylsulphide Effect Antimutagenic Immune
http://linked.open...ontrolniKodProRIV	[31FFC7312687]
http://linked.open...i/riv/mistoVydani	Aberdeen
http://linked.open...i/riv/nazevZdroje	EUROPEAN Environmental Mutagen Society
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Antimutagenic and immunomodulative effects of selected natural substances.
http://linked.open...UplatneniVysledku	2003
http://linked.open...iv/tvurceVysledku	Anděl, Michal Bártová, Jiřina Bárta, Ivo Polívková, Zdeňka Šmerák, Petr Langová, Martina
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111200001
number of pages	2 (xsd:int)
http://purl.org/ne...btex#hasPublisher	EEMS
http://localhost/t...ganizacniJednotka	11120

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