About: A re-assessment of styrene-induced clastogenicity in mice in a subacute inhalation study

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About: A re-assessment of styrene-induced clastogenicity in mice in a subacute inhalation study Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1007/s00204-002-0406-y
Description	To date, a number of in vivo cytogenetic assays have studied the clastogenicity (chromosome aberrations, micronuclei formacion) in bone marrow of rodents exposed to styrene by various routes. NMRI mice were exposed by whole body inhalation to styrene concentrations of 750 mg/m3 and 1,500 mg/ m3 for 1, 3, 7, 14 and 21consecutive days (6 h/day). Animals were killed directly after exposure and bone marrow was sampled for analysis of micronucleus induction. Under the experimental conditions used in the present investigation, there was no evidence of clastogenicity at any concentration or exposure interval. To date, a number of in vivo cytogenetic assays have studied the clastogenicity (chromosome aberrations, micronuclei formacion) in bone marrow of rodents exposed to styrene by various routes. NMRI mice were exposed by whole body inhalation to styrene concentrations of 750 mg/m3 and 1,500 mg/ m3 for 1, 3, 7, 14 and 21consecutive days (6 h/day). Animals were killed directly after exposure and bone marrow was sampled for analysis of micronucleus induction. Under the experimental conditions used in the present investigation, there was no evidence of clastogenicity at any concentration or exposure interval. (en)
Title	A re-assessment of styrene-induced clastogenicity in mice in a subacute inhalation study A re-assessment of styrene-induced clastogenicity in mice in a subacute inhalation study (en)
skos:prefLabel	A re-assessment of styrene-induced clastogenicity in mice in a subacute inhalation study A re-assessment of styrene-induced clastogenicity in mice in a subacute inhalation study (en)
skos:notation	RIV/00216208:11120/03:00003011!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z5039906), Z(MSM 111200001)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Vodička, Pavel Bárta, Ivo
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	597104
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/03:00003011
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	styrene; micronucleus assay; clastogenicity; inhalation (en)
http://linked.open.../riv/klicoveSlovo	inhalation clastogenicity micronucleus assay styrene
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[53FE940F01E6]
http://linked.open...i/riv/nazevZdroje	Archives of Toxicology
http://linked.open...in/vavai/riv/obor	FM
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	77
http://linked.open...iv/tvurceVysledku	Vodička, Pavel Bárta, Ivo Engelhardt, G.
http://linked.open...ain/vavai/riv/wos	000180851000012
http://linked.open...n/vavai/riv/zamer	The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111200001
issn	0340-5761
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s00204-002-0406-y
http://localhost/t...ganizacniJednotka	11120

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