About: Genetic variants of homocysteine metabolizing enzymes and the risk of coronary artery disease

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Genetic variants of homocysteine metabolizing enzymes and the risk of coronary artery disease Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	It is unresolved whether elevated homocysteine in coronary artery disease (CAD) is the cause of arteriosclerosis or its consequence. In contrast, genetic variants of enzymes that metabolize homocysteine cannot be altered by arteriosclerosis. Consequently, their association with CAD would permit to imply causality. We modeled by regression analysis the effect of 11 variants in the methionine cycle upon CAD manifestation in 591 controls and 278 CAD patients. Among the examined variants only the carriership, for the c.844ins68 in the cystathionine beta-synthase (CBS) gene was associated with a significantly lowered risk of CAD (OR = 0.56; 95% CI = 0.35-0.90 in the univariable, and OR = 0.41, 95% CI = 0.19-0.89 for obese people in the multivariable analysis, respectively). Healthy carriers of the c.844ins68 variant exhibited, compared to the wild type controls, significantly higher postload ratios of blood S-adenosylmethionine to S-adenosylhomocysteine (61.4 vs. 54.9, p = 0.001) and of plasma total cystei It is unresolved whether elevated homocysteine in coronary artery disease (CAD) is the cause of arteriosclerosis or its consequence. In contrast, genetic variants of enzymes that metabolize homocysteine cannot be altered by arteriosclerosis. Consequently, their association with CAD would permit to imply causality. We modeled by regression analysis the effect of 11 variants in the methionine cycle upon CAD manifestation in 591 controls and 278 CAD patients. Among the examined variants only the carriership, for the c.844ins68 in the cystathionine beta-synthase (CBS) gene was associated with a significantly lowered risk of CAD (OR = 0.56; 95% CI = 0.35-0.90 in the univariable, and OR = 0.41, 95% CI = 0.19-0.89 for obese people in the multivariable analysis, respectively). Healthy carriers of the c.844ins68 variant exhibited, compared to the wild type controls, significantly higher postload ratios of blood S-adenosylmethionine to S-adenosylhomocysteine (61.4 vs. 54.9, p = 0.001) and of plasma total cystei (en)
Title	Genetic variants of homocysteine metabolizing enzymes and the risk of coronary artery disease Genetic variants of homocysteine metabolizing enzymes and the risk of coronary artery disease (en)
skos:prefLabel	Genetic variants of homocysteine metabolizing enzymes and the risk of coronary artery disease Genetic variants of homocysteine metabolizing enzymes and the risk of coronary artery disease (en)
skos:notation	RIV/00216208:11120/03:00002204!RIV11-MZ0-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NM26), P(NM6548), Z(MSM 111100003)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Anděl, M. Kraml, P. Vítová, Andrea
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	608156
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/03:00002204
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	coronary disease; risk factors; genes; homocysteine; metabolism (en)
http://linked.open.../riv/klicoveSlovo	risk factors homocysteine coronary disease metabolism genes
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[85F31848ABC3]
http://linked.open...i/riv/nazevZdroje	Molecular Genetics and Metabolism
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...vavai/riv/projekt	Complication of pregnancy associated with hyperhomocysteinemia: the role of genetic variants in the development of neural tube defects, orofacial clefts, and preeclampsia Mild hyperhomocysteinemia in the Czech population: analysis of genetic factors among patients with atherosclerosis.
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	79
http://linked.open...iv/tvurceVysledku	Vítová, Andrea Anděl, Michal Kraml, Pavel Janošíková, B.
http://linked.open...ain/vavai/riv/wos	000184304300003
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111100003
issn	1096-7192
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 9 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software