About: The localization of nuclear DNA helicase II in different nuclear compartments is linked to transcription

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About: The localization of nuclear DNA helicase II in different nuclear compartments is linked to transcription Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1006/excr.2002.5617
Description	Nuclear DNA helicase II (NDH II) is a member of the DEAH superfamily of helicases and functions as a pre-mRNA- and mRNA-binding protein in human cells. Here we report for the first time that human NDH II is associated with the nucleolus of transformed and non-transformed cells as shown by immunofluorescence and by ultrastructural studies. When RNA polymerase II (POL II) transcription is inhibited, NDH II highly accumulates in the nucleolus and shows predominant association with subdomains in DFC and in a portion of GC attached to DFC. Furthermore, these subdomains completely co-localize with mRNA-binding protein TLS. In addition, we show that nucleolar accumulation of NDH II is closely related to Go-phase growth arrest in human fibroblasts. Thus, the nucleolar localization of NDH II depends upon the metabolic state of the cell. Based on the data we propose that NDH II operates in both nucleoplasmic and nucleolar mode, and that its redistribution reflects accumulations indicating a possible cycling of Nuclear DNA helicase II (NDH II) is a member of the DEAH superfamily of helicases and functions as a pre-mRNA- and mRNA-binding protein in human cells. Here we report for the first time that human NDH II is associated with the nucleolus of transformed and non-transformed cells as shown by immunofluorescence and by ultrastructural studies. When RNA polymerase II (POL II) transcription is inhibited, NDH II highly accumulates in the nucleolus and shows predominant association with subdomains in DFC and in a portion of GC attached to DFC. Furthermore, these subdomains completely co-localize with mRNA-binding protein TLS. In addition, we show that nucleolar accumulation of NDH II is closely related to Go-phase growth arrest in human fibroblasts. Thus, the nucleolar localization of NDH II depends upon the metabolic state of the cell. Based on the data we propose that NDH II operates in both nucleoplasmic and nucleolar mode, and that its redistribution reflects accumulations indicating a possible cycling of (en)
Title	The localization of nuclear DNA helicase II in different nuclear compartments is linked to transcription The localization of nuclear DNA helicase II in different nuclear compartments is linked to transcription (en)
skos:prefLabel	The localization of nuclear DNA helicase II in different nuclear compartments is linked to transcription The localization of nuclear DNA helicase II in different nuclear compartments is linked to transcription (en)
skos:notation	RIV/00216208:11120/02:00003810!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(IAA5039202), V, Z(AV0Z5039906)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hozák, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	652003
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/02:00003810
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	alpha-amanitin; actinomycin D; DRB; nuclear DNA helicase II; nucleolus; RNA helicase A; RNA polymerase II; transcription (en)
http://linked.open.../riv/klicoveSlovo	DRB transcription RNA polymerase II RNA helicase A actinomycin D alpha-amanitin nuclear DNA helicase II nucleolus
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[06F43D290108]
http://linked.open...i/riv/nazevZdroje	Experimental Cell Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular anatomy of structures directing nuclear compartmentalization
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	279
http://linked.open...iv/tvurceVysledku	Hozák, Pavel Fuchsová, Beáta
http://linked.open...ain/vavai/riv/wos	000178224700009
http://linked.open...n/vavai/riv/zamer	The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy
issn	0014-4827
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1006/excr.2002.5617
http://localhost/t...ganizacniJednotka	11120

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