About: Developments in hematopoietic stem-cell transplantation in the treatment of autoimmune diseases

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About: Developments in hematopoietic stem-cell transplantation in the treatment of autoimmune diseases Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ima.org.il/imaj/ar02apr-8.pdf
Description	Intractable forms of autoimmune diseases follow a rapid course, with a significantly shortened life. expectancy sometimes comparable to that of malignant diseases. Immunoablative therapy; including high dose cytotoxic agents and hematopoietic autologous stem-cell rescue, was recently introduced as an aggressive approach to treat autoimmune diseases that-have a rapid course and are resistant to conventional therapy. The most frequent indication for this type of treatment is multiple sclerosis, seconded by systemic sclerosis. The results of immunoablative treatment with documented responses in both diseases are encouraging. The data are mature enough to begin comparative randomized studies of immunoablative versus conventional treatment to validate the benefit, of the aggressive approach. A randomized trial involving SSc was recently launched (ASTIS) and a trial involving MS is in preparation: Considerably less experience with; immunoablative treatment has, been gained in systemic lupus erythematosus, r Intractable forms of autoimmune diseases follow a rapid course, with a significantly shortened life. expectancy sometimes comparable to that of malignant diseases. Immunoablative therapy; including high dose cytotoxic agents and hematopoietic autologous stem-cell rescue, was recently introduced as an aggressive approach to treat autoimmune diseases that-have a rapid course and are resistant to conventional therapy. The most frequent indication for this type of treatment is multiple sclerosis, seconded by systemic sclerosis. The results of immunoablative treatment with documented responses in both diseases are encouraging. The data are mature enough to begin comparative randomized studies of immunoablative versus conventional treatment to validate the benefit, of the aggressive approach. A randomized trial involving SSc was recently launched (ASTIS) and a trial involving MS is in preparation: Considerably less experience with; immunoablative treatment has, been gained in systemic lupus erythematosus, r (en)
Title	Developments in hematopoietic stem-cell transplantation in the treatment of autoimmune diseases Developments in hematopoietic stem-cell transplantation in the treatment of autoimmune diseases (en)
skos:prefLabel	Developments in hematopoietic stem-cell transplantation in the treatment of autoimmune diseases Developments in hematopoietic stem-cell transplantation in the treatment of autoimmune diseases (en)
skos:notation	RIV/00216208:11120/02:00003703!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 111200002)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kozák, Tomáš Rychlík, Ivan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	642923
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/02:00003703
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	stem cell; transplantation; autoimmune disease; immunosuppression (en)
http://linked.open.../riv/klicoveSlovo	autoimmune disease stem cell transplantation immunosuppression
http://linked.open...odStatuVydavatele	IL - Stát Izrael
http://linked.open...ontrolniKodProRIV	[C20A984FB5A6]
http://linked.open...i/riv/nazevZdroje	Israel Medical Association Journal
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	4
http://linked.open...iv/tvurceVysledku	Kozák, Tomáš Rychlík, Ivan
http://linked.open...ain/vavai/riv/wos	000182574000008
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111200002
issn	1565-1088
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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