About: Embryotoxicity of cisplatin nad a cisplatin-procaine complex (DPR) studied in chick embryo

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About: Embryotoxicity of cisplatin nad a cisplatin-procaine complex (DPR) studied in chick embryo Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cisplatin is widely used as an antitumor drug. To reduce its toxic side effects in patients, cisplatin has been bound with procaine in a cisplatin-procaine complex (DPR). The lethal and teratogenic effects of cisplatin alone and of complexcd cisplatin were determined in the chick embryo in ovo in order to compare their influence on rapidly proliferating embryonic tissues. The embryotoxic (lethal + teratogenic) effect was examined after a single intra-amniotic injection of one of six different doses, ranging from 0.03 to30.0 mug, on embryonic days (ED) 3, 4 or 5. The minimal embryotoxic dose was lower for cisplatin alone (0.03-0.3 mug) than for cisplatin in the DPR complex (0.3-3.0 mug), suggesting that cisplatin alone is more embryotoxic than complexed cisplatin. Both substances caused malformations in the surviving embryos evaluated on ED 9. These malformations included microphthalmia, Microcephaly, hypoplasia of the upper and lower jaw, cleft beak, and haemocephaly. Moreover. heart septum defects an Cisplatin is widely used as an antitumor drug. To reduce its toxic side effects in patients, cisplatin has been bound with procaine in a cisplatin-procaine complex (DPR). The lethal and teratogenic effects of cisplatin alone and of complexcd cisplatin were determined in the chick embryo in ovo in order to compare their influence on rapidly proliferating embryonic tissues. The embryotoxic (lethal + teratogenic) effect was examined after a single intra-amniotic injection of one of six different doses, ranging from 0.03 to30.0 mug, on embryonic days (ED) 3, 4 or 5. The minimal embryotoxic dose was lower for cisplatin alone (0.03-0.3 mug) than for cisplatin in the DPR complex (0.3-3.0 mug), suggesting that cisplatin alone is more embryotoxic than complexed cisplatin. Both substances caused malformations in the surviving embryos evaluated on ED 9. These malformations included microphthalmia, Microcephaly, hypoplasia of the upper and lower jaw, cleft beak, and haemocephaly. Moreover. heart septum defects an (en)
Title	Embryotoxicity of cisplatin nad a cisplatin-procaine complex (DPR) studied in chick embryo Embryotoxicity of cisplatin nad a cisplatin-procaine complex (DPR) studied in chick embryo (en)
skos:prefLabel	Embryotoxicity of cisplatin nad a cisplatin-procaine complex (DPR) studied in chick embryo Embryotoxicity of cisplatin nad a cisplatin-procaine complex (DPR) studied in chick embryo (en)
skos:notation	RIV/00216208:11120/02:00003696!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Mandys, Václav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	644930
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/02:00003696
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cisplatin; cisplatin procaine complex DPR; teratogen; malformation (en)
http://linked.open.../riv/klicoveSlovo	malformation cisplatin cisplatin procaine complex DPR teratogen
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[EC862746FA7B]
http://linked.open...i/riv/nazevZdroje	Neoplasma
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	49
http://linked.open...iv/tvurceVysledku	Peterka, Miroslav Mandys, Václav
http://linked.open...ain/vavai/riv/wos	000180614700007
issn	0028-2685
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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