About: The neuronal nitric oxide synthase gene is critically involved in neurobehavioral effects of alcohol

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About: The neuronal nitric oxide synthase gene is critically involved in neurobehavioral effects of alcohol Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.jneurosci.org/content/22/19/8676.long
Description	In the present study, we describe a new role of the neuronal nitric oxide synthase (nNOS) gene in the regulation of alcohol drinking behavior. Mice deficient in the nNOS gene (nNOS-/-) and wild-type control mice were submitted to a two-bottle free-choice procedure with either water or increasing concentrations of alcohol (2-16%) for 6 weeks. nNOS-/- mice did not differ in consumption and preference for low alcohol concentrations from wild-type animals; however, nNOS-/- mice consumed sixfold more alcohol from highly concentrated alcohol solutions than wild-type mice. Taste studies with either sucrose or quinine solutions revealed that alcohol intake in nNOS -/- and wild-type mice is associated, at least in part, with sweet solution intake but not with the taste of bitterness. When compared with wild-type mice, the nNOS-/- mice were found to be less sensitive to the sedative effects of ethanol as measured by shorter recovery time from ethanol-induced sleep and did not develop rapid tolerance to ethanol- In the present study, we describe a new role of the neuronal nitric oxide synthase (nNOS) gene in the regulation of alcohol drinking behavior. Mice deficient in the nNOS gene (nNOS-/-) and wild-type control mice were submitted to a two-bottle free-choice procedure with either water or increasing concentrations of alcohol (2-16%) for 6 weeks. nNOS-/- mice did not differ in consumption and preference for low alcohol concentrations from wild-type animals; however, nNOS-/- mice consumed sixfold more alcohol from highly concentrated alcohol solutions than wild-type mice. Taste studies with either sucrose or quinine solutions revealed that alcohol intake in nNOS -/- and wild-type mice is associated, at least in part, with sweet solution intake but not with the taste of bitterness. When compared with wild-type mice, the nNOS-/- mice were found to be less sensitive to the sedative effects of ethanol as measured by shorter recovery time from ethanol-induced sleep and did not develop rapid tolerance to ethanol- (en)
Title	The neuronal nitric oxide synthase gene is critically involved in neurobehavioral effects of alcohol The neuronal nitric oxide synthase gene is critically involved in neurobehavioral effects of alcohol (en)
skos:prefLabel	The neuronal nitric oxide synthase gene is critically involved in neurobehavioral effects of alcohol The neuronal nitric oxide synthase gene is critically involved in neurobehavioral effects of alcohol (en)
skos:notation	RIV/00216208:11120/02:00003647!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	N
http://linked.open...avai/riv/aktivity	N
http://linked.open...iv/cisloPeriodika	19
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Šustková, Magdaléna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	655429
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/02:00003647
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	neuronal nitric oxide synthase; nNOS; nNOS splice variants; knock-out mice; alcohol drinking; taste differences; loss of righting reflex; rapid tolerance; NOS inhibitors (en)
http://linked.open.../riv/klicoveSlovo	neuronal nitric oxide synthase alcohol drinking nNOS knock-out mice loss of righting reflex nNOS splice variants rapid tolerance taste differences NOS inhibitors
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[78BD7C56CA1A]
http://linked.open...i/riv/nazevZdroje	Journal of Neuroscience
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	22
http://linked.open...iv/tvurceVysledku	Fišerová, Magdaléna Spanagel, R.
http://linked.open...ain/vavai/riv/wos	000178246000036
issn	0270-6474
number of pages	19 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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