About: Increased lipolysis in adipose tissue and lipid mobilization to natriuretic peptides during low-calorie diet in obese women

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About: Increased lipolysis in adipose tissue and lipid mobilization to natriuretic peptides during low-calorie diet in obese women Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1038/sj/ijo/0801845
Description	We recently demonstrated that natriuretic peptides (NP) are involved in a pathway inducing lipolysis in human adipose tissue. Atrial NP (ANP) and brain NP (BNP) operate via a cGMP-dependent pathway which does not involve phosphodiesterase-3B inhibition or CAMP. The study was performed to evaluate the effect of ANP on lipid mobilization in obese women and secondly to examine the possible effect of a low-calorie diet (LCD) on the lipolytic response of subcutaneous abdominal fat cells to NP and on the lipid mobilization induced by ANP infusion (1 mug/m(2) min for 60 min). CONCLUSION: The present study shows that NP are powerful lipolytic agents in subcutaneous fat cells and that both isoproterenol- and NP-induced lipolysis increase during LCD, in obese women. These changes seem to be associated with an improvement of the lipolytic pathway at a post-receptor level. Moreover, Lv. administration of ANP induced a lipid mobilizing effect which was enhanced by a LCD in these objects. We recently demonstrated that natriuretic peptides (NP) are involved in a pathway inducing lipolysis in human adipose tissue. Atrial NP (ANP) and brain NP (BNP) operate via a cGMP-dependent pathway which does not involve phosphodiesterase-3B inhibition or CAMP. The study was performed to evaluate the effect of ANP on lipid mobilization in obese women and secondly to examine the possible effect of a low-calorie diet (LCD) on the lipolytic response of subcutaneous abdominal fat cells to NP and on the lipid mobilization induced by ANP infusion (1 mug/m(2) min for 60 min). CONCLUSION: The present study shows that NP are powerful lipolytic agents in subcutaneous fat cells and that both isoproterenol- and NP-induced lipolysis increase during LCD, in obese women. These changes seem to be associated with an improvement of the lipolytic pathway at a post-receptor level. Moreover, Lv. administration of ANP induced a lipid mobilizing effect which was enhanced by a LCD in these objects. (en)
Title	Increased lipolysis in adipose tissue and lipid mobilization to natriuretic peptides during low-calorie diet in obese women Increased lipolysis in adipose tissue and lipid mobilization to natriuretic peptides during low-calorie diet in obese women (en)
skos:prefLabel	Increased lipolysis in adipose tissue and lipid mobilization to natriuretic peptides during low-calorie diet in obese women Increased lipolysis in adipose tissue and lipid mobilization to natriuretic peptides during low-calorie diet in obese women (en)
skos:notation	RIV/00216208:11120/02:00003123!RIV12-MZ0-11120___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NB4674)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hejnová, Jindřiška Štich, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	648686
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/02:00003123
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ANP; BNP; adipocytes; fat cells; lipolysis; microdialysis (en)
http://linked.open.../riv/klicoveSlovo	BNP lipolysis ANP microdialysis adipocytes fat cells
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[8D0DA07C1975]
http://linked.open...i/riv/nazevZdroje	International Journal of Obesity
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Metabolism of adipose tissue examined by methods of molecular biology in obese subjects from regions with different risk of cardiovascular diseases.
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	26
http://linked.open...iv/tvurceVysledku	Štich, Vladimír Hejnová, Jindřiška
http://linked.open...ain/vavai/riv/wos	000173366200004
issn	0307-0565
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1038/sj/ijo/0801845
http://localhost/t...ganizacniJednotka	11120

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