About: Effect of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune responsiveness of mice     Goto   Sponge   NotDistinct   Permalink

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Description
  • The involvement of catecholamine receptors (alpha-adrenergic, D2-dopamine (DA)) was investigated in restraint stress influenced immune responses with concomitant changes of G-protein signal transduction. Impairment of the spleen morphology, TH1/TH2 cytokine network and natural killer (NK) cell function was observed. In vivo administration of specific antagonists prior to restraint stress reversed the immunosuppression. These findings demonstrate that D2-type dopaminergic mechanism represents the dominant component in regulation of Galphas/Galphai(1,2)/Galphaq/11-protein signal transduction and contribute to cell responses at postreceptor level of both, central nervous and immune systems. G-protein-coupled receptors (GPCRs) can modulate cytokine production and may play a regulatory role in immune effector mechanisms
  • The involvement of catecholamine receptors (alpha-adrenergic, D2-dopamine (DA)) was investigated in restraint stress influenced immune responses with concomitant changes of G-protein signal transduction. Impairment of the spleen morphology, TH1/TH2 cytokine network and natural killer (NK) cell function was observed. In vivo administration of specific antagonists prior to restraint stress reversed the immunosuppression. These findings demonstrate that D2-type dopaminergic mechanism represents the dominant component in regulation of Galphas/Galphai(1,2)/Galphaq/11-protein signal transduction and contribute to cell responses at postreceptor level of both, central nervous and immune systems. G-protein-coupled receptors (GPCRs) can modulate cytokine production and may play a regulatory role in immune effector mechanisms (en)
Title
  • Effect of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune responsiveness of mice
  • Effect of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune responsiveness of mice (en)
skos:prefLabel
  • Effect of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune responsiveness of mice
  • Effect of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune responsiveness of mice (en)
skos:notation
  • RIV/00216208:11120/02:00002993!RIV12-GA0-11120___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA310/98/0347)
http://linked.open...iv/cisloPeriodika
  • 1-2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 644175
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11120/02:00002993
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • restraint stress; cytokine; NK cell (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [D69ED90D69B0]
http://linked.open...i/riv/nazevZdroje
  • Journal of Neuroimmunology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 130
http://linked.open...iv/tvurceVysledku
  • Fišerová, Anna
  • Starec, Miroslav
http://linked.open...ain/vavai/riv/wos
  • 000178329200006
issn
  • 0165-5728
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/s0165-5728(02)00211-4
http://localhost/t...ganizacniJednotka
  • 11120
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