About: Genotoxic Effects of Selected Trichothecene Mycotoxins and Their Combinations with Aflatoxin B1

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The authors focused on the amplification of data on the mutagenicity of selected trichothecene mycotoxins (T-2 toxin, vomitoxin) and their combination with aflatoxin B1 which is known to be a strong mutagen. Mutagenic activity was investigated with the aid of the Ames test in the prokaryote model at low doses (close to 0.1 LD50). While the individual trichothecene mycotoxins (T-2 toxin, vomitoxin) did not show any mutagenic activity in the test systems mentioned, in combination with AFB1, or as a combination of all three mycotoxins, they showed in the Ames test (in strain TA98 at all concentrations) as well as in the micronucleus test (combination of T-2 toxin with AFB1) a mutagenic effect significantly greater than that of just AFB1 alone. The authors focused on the amplification of data on the mutagenicity of selected trichothecene mycotoxins (T-2 toxin, vomitoxin) and their combination with aflatoxin B1 which is known to be a strong mutagen. Mutagenic activity was investigated with the aid of the Ames test in the prokaryote model at low doses (close to 0.1 LD50). While the individual trichothecene mycotoxins (T-2 toxin, vomitoxin) did not show any mutagenic activity in the test systems mentioned, in combination with AFB1, or as a combination of all three mycotoxins, they showed in the Ames test (in strain TA98 at all concentrations) as well as in the micronucleus test (combination of T-2 toxin with AFB1) a mutagenic effect significantly greater than that of just AFB1 alone. (en)
Title	Genotoxic Effects of Selected Trichothecene Mycotoxins and Their Combinations with Aflatoxin B1 Genotoxic Effects of Selected Trichothecene Mycotoxins and Their Combinations with Aflatoxin B1 (en)
skos:prefLabel	Genotoxic Effects of Selected Trichothecene Mycotoxins and Their Combinations with Aflatoxin B1 Genotoxic Effects of Selected Trichothecene Mycotoxins and Their Combinations with Aflatoxin B1 (en)
skos:notation	RIV/00216208:11120/01:00110188!RIV/2002/MZ0/111202/N
http://linked.open.../vavai/riv/strany	90;96
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IZ4147), Z(MSM 111200001)
http://linked.open...iv/cisloPeriodika	June
http://linked.open...vai/riv/dodaniDat	2002
http://linked.open...aciTvurceVysledku	Šmerák, Petr Polívková, Zdeňka Bártová, Jiřina Bárta, Ivo
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	681111
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/01:00110188
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Genotoxic;Effects;Selected;Trichothecene;Mycotoxins;Their;Combinations;Aflatoxin;B1 (en)
http://linked.open.../riv/klicoveSlovo	Selected Their Trichothecene Mycotoxins B1 Combinations Aflatoxin Effects Genotoxic
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[59896F3AC949]
http://linked.open...i/riv/nazevZdroje	Czech Journal of Food Sciences
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Biological effects of selected mycotoxins and their combinations
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Bártová, Jiřina Bárta, Ivo Polívková, Zdeňka Šmerák, Petr
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111200001
issn	1212-1800
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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