About: The nucleoskeleton: A permanent structure of cell nuclei regardless of their transcriptional activity

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About: The nucleoskeleton: A permanent structure of cell nuclei regardless of their transcriptional activity Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1006/excr.2001.5150
Description	Nuclear matrix or nucleoskeleton is thought to provide structural basis for intranuclear order. However, the nature of this structure is still uncertain because of numerous technical difficulties in its visualization. To reveal the %22real%22 morphology of the nucleoskeleton, and to identify possible sources of structural artifacts, three methods of nucleoskeleton preparations were compared. The nucleoskeleton visualized by all these techniques consists of identical elements: nuclear lamina and an inner network comprising core filaments and the %22diffuse%22 nucleoskeleton. We then tested if the nucleoskeleton is a stable structure or a transient transcription-dependent structure. Incubation with transcription inhibitors (cu-amanitin, actinomycin D, and DRB) for various periods of time had no obvious effect on the morphology of the nucleoskeleton. A typical nucleoskeleton structure was observed also in a physiological model - in transcriptionally inactive mouse 2-cell embryos and in active Nuclear matrix or nucleoskeleton is thought to provide structural basis for intranuclear order. However, the nature of this structure is still uncertain because of numerous technical difficulties in its visualization. To reveal the %22real%22 morphology of the nucleoskeleton, and to identify possible sources of structural artifacts, three methods of nucleoskeleton preparations were compared. The nucleoskeleton visualized by all these techniques consists of identical elements: nuclear lamina and an inner network comprising core filaments and the %22diffuse%22 nucleoskeleton. We then tested if the nucleoskeleton is a stable structure or a transient transcription-dependent structure. Incubation with transcription inhibitors (cu-amanitin, actinomycin D, and DRB) for various periods of time had no obvious effect on the morphology of the nucleoskeleton. A typical nucleoskeleton structure was observed also in a physiological model - in transcriptionally inactive mouse 2-cell embryos and in active (en)
Title	The nucleoskeleton: A permanent structure of cell nuclei regardless of their transcriptional activity The nucleoskeleton: A permanent structure of cell nuclei regardless of their transcriptional activity (en)
skos:prefLabel	The nucleoskeleton: A permanent structure of cell nuclei regardless of their transcriptional activity The nucleoskeleton: A permanent structure of cell nuclei regardless of their transcriptional activity (en)
skos:notation	RIV/00216208:11120/01:00003678!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(GA304/98/1035), P(IAA5039701), V, Z(AV0Z5039906)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hozák, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	689262
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/01:00003678
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cell nucleus; ultrastructure; nucleoskeleton; nuclear matrix; transcription; early mammalian development; mouse (en)
http://linked.open.../riv/klicoveSlovo	ultrastructure cell nucleus transcription nuclear matrix early mammalian development nucleoskeleton mouse
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[CFFC2B60820D]
http://linked.open...i/riv/nazevZdroje	Experimental Cell Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Intranuclear movement and gene expression Functional microarchitecture of the nucleoskeleton
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	264
http://linked.open...iv/tvurceVysledku	Hozák, Pavel Philimonenko, Vlada V. Flechon, Jacques-Edmond
http://linked.open...ain/vavai/riv/wos	000167845100002
http://linked.open...n/vavai/riv/zamer	The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy
issn	0014-4827
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1006/excr.2001.5150
http://localhost/t...ganizacniJednotka	11120

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