About: Clozapine-induced concordant agranulocytosis in monozygotic twins

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About: Clozapine-induced concordant agranulocytosis in monozygotic twins Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1080/136515001300225231
Description	Two monozygotic twin sisters were admitted to a psychiatric hospital and diagnosed as having first-episode schizophrenia. Clozapine treatment led to the complete remission of psychotic symptoms within a short time. In both twins the low leukocyte count was detected after 9 weeks of clozapine. Serological typing of the HLA system was performed and an identical pattern was detected in both twins: HLA-A: 28, 26; HLA-B: 49, 63; DR: 2 (vs 16), 12, 52; DQ:1. It is the first report of concordant manifestation of clozapine-induced agranulocytosis in monozygotic twins. Our ease report of twins afflicted synchronously with schizophrenia and Inter with agranulocytosis after clozapine is of interest because it suggests that genetic factors may participate not only in timing of onset of schizophrenia, but also in the emergence and timing of agranulocytosis in response to clozapine treatment. Two monozygotic twin sisters were admitted to a psychiatric hospital and diagnosed as having first-episode schizophrenia. Clozapine treatment led to the complete remission of psychotic symptoms within a short time. In both twins the low leukocyte count was detected after 9 weeks of clozapine. Serological typing of the HLA system was performed and an identical pattern was detected in both twins: HLA-A: 28, 26; HLA-B: 49, 63; DR: 2 (vs 16), 12, 52; DQ:1. It is the first report of concordant manifestation of clozapine-induced agranulocytosis in monozygotic twins. Our ease report of twins afflicted synchronously with schizophrenia and Inter with agranulocytosis after clozapine is of interest because it suggests that genetic factors may participate not only in timing of onset of schizophrenia, but also in the emergence and timing of agranulocytosis in response to clozapine treatment. (en)
Title	Clozapine-induced concordant agranulocytosis in monozygotic twins Clozapine-induced concordant agranulocytosis in monozygotic twins (en)
skos:prefLabel	Clozapine-induced concordant agranulocytosis in monozygotic twins Clozapine-induced concordant agranulocytosis in monozygotic twins (en)
skos:notation	RIV/00216208:11120/01:00003674!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 111200005)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Höschl, Cyril Horáček, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	675766
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/01:00003674
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	clozapine; agranulocytosis; monozygotic twins; genetic factors; timing (en)
http://linked.open.../riv/klicoveSlovo	timing clozapine genetic factors monozygotic twins agranulocytosis
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D62345AD1148]
http://linked.open...i/riv/nazevZdroje	International Journal of Psychiatry in Clinical Practice
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Horáček, Jiří Höschl, Cyril
http://linked.open...ain/vavai/riv/wos	000168420100012
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111200005
issn	1365-1501
number of pages	3 (xsd:int)
http://bibframe.org/vocab/doi	10.1080/136515001300225231
http://localhost/t...ganizacniJednotka	11120

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