About: Antitumour activity of N-6-substituted PMEDAP derivatives against T-cell lymphoma

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About: Antitumour activity of N-6-substituted PMEDAP derivatives against T-cell lymphoma Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The antitumour activity of four N-6-substituted PMEDAP derivatives, Me2NEt-PMEDAP, allyl-PMEDAP, Me-2-PMEDAP and cypr-PMEDAP, selected on the basis of their in vitro cytostatic activity, was studied in an in vivo model of haematological malignancy of inbred Sprague-Dawley rats. These compounds are believed to serve as the prodrugs of another (phosphonomethoxy) ethyl derivative, PMEG (9-[2-phosphonomethoxy) ethyl] guanine. We compared their toxicity and ability to inhibit tumour development in two different dosage regimes with those of their parent compound PMEDAP, as well with PMEG. The study confirmed the anticancer efficacy of the parental compound PMEDAP. Unlike PMEDAP, its N-6-mono- and disubstituted congeners Me2NEt-PMEDAP, allyl-PMEDAP and Me-2-PMEDAP were less potent or exhibited the same antineoplastic effect as PMEDAP. cypr-PMEDAP significantly decreased the survival of lymphoma-bearing rats due to high toxicity, which was approximately the same as that of PMEG, Therefore, these acyclic nucle The antitumour activity of four N-6-substituted PMEDAP derivatives, Me2NEt-PMEDAP, allyl-PMEDAP, Me-2-PMEDAP and cypr-PMEDAP, selected on the basis of their in vitro cytostatic activity, was studied in an in vivo model of haematological malignancy of inbred Sprague-Dawley rats. These compounds are believed to serve as the prodrugs of another (phosphonomethoxy) ethyl derivative, PMEG (9-[2-phosphonomethoxy) ethyl] guanine. We compared their toxicity and ability to inhibit tumour development in two different dosage regimes with those of their parent compound PMEDAP, as well with PMEG. The study confirmed the anticancer efficacy of the parental compound PMEDAP. Unlike PMEDAP, its N-6-mono- and disubstituted congeners Me2NEt-PMEDAP, allyl-PMEDAP and Me-2-PMEDAP were less potent or exhibited the same antineoplastic effect as PMEDAP. cypr-PMEDAP significantly decreased the survival of lymphoma-bearing rats due to high toxicity, which was approximately the same as that of PMEG, Therefore, these acyclic nucle (en)
Title	Antitumour activity of N-6-substituted PMEDAP derivatives against T-cell lymphoma Antitumour activity of N-6-substituted PMEDAP derivatives against T-cell lymphoma (en)
skos:prefLabel	Antitumour activity of N-6-substituted PMEDAP derivatives against T-cell lymphoma Antitumour activity of N-6-substituted PMEDAP derivatives against T-cell lymphoma (en)
skos:notation	RIV/00216208:11120/01:00003665!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GV203/96/K128), P(NL5423), Z(AV0Z4055905), Z(AV0Z5039906), Z(MSM 111200002)
http://linked.open...iv/cisloPeriodika	3B
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Mandys, Václav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	673535
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/01:00003665
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	rat; spontaneous lymphoma; PMEDAP derivatives (en)
http://linked.open.../riv/klicoveSlovo	rat PMEDAP derivatives spontaneous lymphoma
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[2938ACEC1014]
http://linked.open...i/riv/nazevZdroje	Anticancer Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Capillary electromigration methods and their application for the separation of proteins and peptides 9-(2-Phosphonomethoxyethyl)-2, 6-dianomipurine (PMEDAP) and derivatives: potencial drugs against hematological malignancies
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Mandys, Václav Valeriánová, M.
http://linked.open...ain/vavai/riv/wos	000170276600054
http://linked.open...n/vavai/riv/zamer	The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111200002 Chemical principles of selected biological phenomena in medicine and ecology
issn	0250-7005
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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