About: Prevalence of hereditary non-polyposis colorectal cancer (HNPCC) in Czech patients with endoscopic diagnosis of colorectal cancer     Goto   Sponge   NotDistinct   Permalink

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  • Background and Study Aims: The hereditary non-polyposis colorectal cancer (HNPCC) syndrome is caused by germline mutations in MMR genes and predisposed individuals to cancers of the colon and other specific sites. We assessed the prevalence of HNPCC in Czech patient with endoscopic diagnosis of colorectal cancer. Patient and Methods: We examined 2,464 patients by total colonoscopy. Patient with CRC suspected of HNPCC we screened for germline mutations of mismatch repair genes hMLH1 and hMLH2. Results: Out of a total of 2,464 patients examined 128 were found to have CRC. We found germline mutation in hMLH1 gene in two patients (1.5%). Conclusions: The occurrence of hereditary cancer in Czech patients is lower than suspected, probably in accordance with a high share of sporadic colorectal cancer.
  • Background and Study Aims: The hereditary non-polyposis colorectal cancer (HNPCC) syndrome is caused by germline mutations in MMR genes and predisposed individuals to cancers of the colon and other specific sites. We assessed the prevalence of HNPCC in Czech patient with endoscopic diagnosis of colorectal cancer. Patient and Methods: We examined 2,464 patients by total colonoscopy. Patient with CRC suspected of HNPCC we screened for germline mutations of mismatch repair genes hMLH1 and hMLH2. Results: Out of a total of 2,464 patients examined 128 were found to have CRC. We found germline mutation in hMLH1 gene in two patients (1.5%). Conclusions: The occurrence of hereditary cancer in Czech patients is lower than suspected, probably in accordance with a high share of sporadic colorectal cancer. (en)
Title
  • Prevalence of hereditary non-polyposis colorectal cancer (HNPCC) in Czech patients with endoscopic diagnosis of colorectal cancer
  • Prevalence of hereditary non-polyposis colorectal cancer (HNPCC) in Czech patients with endoscopic diagnosis of colorectal cancer (en)
skos:prefLabel
  • Prevalence of hereditary non-polyposis colorectal cancer (HNPCC) in Czech patients with endoscopic diagnosis of colorectal cancer
  • Prevalence of hereditary non-polyposis colorectal cancer (HNPCC) in Czech patients with endoscopic diagnosis of colorectal cancer (en)
skos:notation
  • RIV/00216208:11120/01:00003660!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 111200001)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 692632
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11120/01:00003660
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Mismatch Repair; Colon-Cancer; Mutations; Frequency; Homolog; Genes (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [CD466455D2C8]
http://linked.open...v/mistoKonaniAkce
  • Praha
http://linked.open...i/riv/mistoVydani
  • Bologna
http://linked.open...i/riv/nazevZdroje
  • 8th Biennial Congress of the European Council of Coloproctology (ECCP)
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Hajer, Jan
  • Zádorová, Zdeňka
  • Kment, Milan
  • Faltýn, Jaroslav
http://linked.open...vavai/riv/typAkce
http://linked.open...ain/vavai/riv/wos
  • 000172544200034
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • Medimond
https://schema.org/isbn
  • 88-323-1429-0
http://localhost/t...ganizacniJednotka
  • 11120
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