About: Combined effects of repeated low doses of aflatoxin B-1 and T-2 toxin on the Chinese hamster

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About: Combined effects of repeated low doses of aflatoxin B-1 and T-2 toxin on the Chinese hamster Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of this work was to find out how repeated low doses of aflatoxin B-1 (AFB(1)) and T-2 toxin would influence the Chinese hamster and if the amplifying of these effects would occur with the application of both toxins together. The animals were treated with 10 ml/kg of 7% dimethylsulfoxid (DMSO) in the control group (C), 1.0 mg/kg of AFB(1) in group A, 1.0 mg/kg of T-2 toxin in group T2, and 1.0 mg/kg of AFB(1) + 1.0 mg/kg of T-2 toxin in group T2/A. All mycotoxins were dissolved in 10 ml/kg of 7% DMSO. These doses were administered intragastrically twice a week for a period of three weeks. General health condition, histological picture of some internal organs, some biochemical blood serum indicators of liver and kidney functions, and leucogram were monitored. No differences in prosperity or weight gains appeared during the course of the experiment. The histological examination did not show any changes in the investigated organs in any experimental group. The aim of this work was to find out how repeated low doses of aflatoxin B-1 (AFB(1)) and T-2 toxin would influence the Chinese hamster and if the amplifying of these effects would occur with the application of both toxins together. The animals were treated with 10 ml/kg of 7% dimethylsulfoxid (DMSO) in the control group (C), 1.0 mg/kg of AFB(1) in group A, 1.0 mg/kg of T-2 toxin in group T2, and 1.0 mg/kg of AFB(1) + 1.0 mg/kg of T-2 toxin in group T2/A. All mycotoxins were dissolved in 10 ml/kg of 7% DMSO. These doses were administered intragastrically twice a week for a period of three weeks. General health condition, histological picture of some internal organs, some biochemical blood serum indicators of liver and kidney functions, and leucogram were monitored. No differences in prosperity or weight gains appeared during the course of the experiment. The histological examination did not show any changes in the investigated organs in any experimental group. (en)
Title	Combined effects of repeated low doses of aflatoxin B-1 and T-2 toxin on the Chinese hamster Combined effects of repeated low doses of aflatoxin B-1 and T-2 toxin on the Chinese hamster (en)
skos:prefLabel	Combined effects of repeated low doses of aflatoxin B-1 and T-2 toxin on the Chinese hamster Combined effects of repeated low doses of aflatoxin B-1 and T-2 toxin on the Chinese hamster (en)
skos:notation	RIV/00216208:11120/01:00003629!RIV12-MZ0-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IZ4147), Z(MSM 412100003)
http://linked.open...iv/cisloPeriodika	11-12
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Šmerák, Petr Bárta, Ivo Sedmíková, Markéta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	675880
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/01:00003629
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mycotoxin; trichothecens; interaction; genotoxicity; differential count (en)
http://linked.open.../riv/klicoveSlovo	genotoxicity interaction mycotoxin differential count trichothecens
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[B40A80DFF79E]
http://linked.open...i/riv/nazevZdroje	Veterinární medicína
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Biological effects of selected mycotoxins and their combinations
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	46
http://linked.open...iv/tvurceVysledku	Rajmon, Radko Sedmíková, Markéta Bárta, Ivo Šmerák, Petr
http://linked.open...ain/vavai/riv/wos	000174103700004
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20412100003
issn	0375-8427
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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