About: Association between genetic polymorphisms and biomarkers in styrene-exposed workers

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/S0027-5107(01)00214-7
Description	A comprehensive approach to evaluate genotoxic effects induced by styrene exposure was employed in 44 hand-lamination workers in comparison with 18 unexposed controls. The acquired data on single-strand breaks in DNA (SSBs), frequency of chromosomal aberrations and HPRT mutant frequency in peripheral blood lymphocytes were compared to the results on genotyping of some of the xenobiotic-metabolising enzymes (CYP1A1, CYP2E1, epoxide hydrolase and GSTM1, GSTP1 and GSTT1). Multifactorial regression analysis indicated that SSB in DNA were significantly associated with styrene exposure and with heterozygosity in CYP2E1 (5'-flanking region and intron 6; r(2)=0.614). The frequency of chromosomal aberrations (CA), as analysed by linear multiple regression analysis, significantly correlated with years of employment (P=0.004) and with combinations of epoxide hydrolase (EPHX) genotypes (exon 3, Tyr/His and exon 4, His/Arg). A comprehensive approach to evaluate genotoxic effects induced by styrene exposure was employed in 44 hand-lamination workers in comparison with 18 unexposed controls. The acquired data on single-strand breaks in DNA (SSBs), frequency of chromosomal aberrations and HPRT mutant frequency in peripheral blood lymphocytes were compared to the results on genotyping of some of the xenobiotic-metabolising enzymes (CYP1A1, CYP2E1, epoxide hydrolase and GSTM1, GSTP1 and GSTT1). Multifactorial regression analysis indicated that SSB in DNA were significantly associated with styrene exposure and with heterozygosity in CYP2E1 (5'-flanking region and intron 6; r(2)=0.614). The frequency of chromosomal aberrations (CA), as analysed by linear multiple regression analysis, significantly correlated with years of employment (P=0.004) and with combinations of epoxide hydrolase (EPHX) genotypes (exon 3, Tyr/His and exon 4, His/Arg). (en)
Title	Association between genetic polymorphisms and biomarkers in styrene-exposed workers Association between genetic polymorphisms and biomarkers in styrene-exposed workers (en)
skos:prefLabel	Association between genetic polymorphisms and biomarkers in styrene-exposed workers Association between genetic polymorphisms and biomarkers in styrene-exposed workers (en)
skos:notation	RIV/00216208:11120/01:00003596!RIV12-GA0-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA313/99/1460), Z(AV0Z5039906)
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Vodička, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	673952
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/01:00003596
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	occupational exposure to styrene; genetic polymorphisms; DNA damage; HPRT mutant frequency; chromosomal aberrations (en)
http://linked.open.../riv/klicoveSlovo	genetic polymorphisms DNA damage chromosomal aberrations HPRT mutant frequency occupational exposure to styrene
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[BBEF500C2260]
http://linked.open...i/riv/nazevZdroje	Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanisms of genotoxic effects and prospects to the evaluation of individual susceptibility to styrene exposure
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	482
http://linked.open...iv/tvurceVysledku	Vodička, Pavel
http://linked.open...ain/vavai/riv/wos	000171083800012
http://linked.open...n/vavai/riv/zamer	The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy
issn	0027-5107
number of pages	15 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/S0027-5107(01)00214-7
http://localhost/t...ganizacniJednotka	11120

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