About: Kinetics of formation of specific styrene oxide adducts in double-stranded DNA

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/S0009-2797(01)00254-X
Description	The possible carcinogenicity of styrene is believed to be related to the DNA-binding properties of styrene 7,8-oxide (SO). In order to compare the intrinsic reactivity of the different nucleophilic sites in DNA towards SO and to evaluate the candidates for human biomonitoring we have determined the second-order rate constants and stabilities of several SO-adducts in double-stranded DNA. These include alpha- and beta -isomers of N7-substituted and alphaN(2)-substituted guanines, alpha- and beta N3-substituted and alphaN(6)-substitated adenines as well as beta N3- and alphaN(4)-substituted cytosines. The highest rate constants were found for the spontaneously depurinating N7-guanines being ca. 3-15-fold higher than those for the stable adducts. When the relative proportions of different alkylation products were determined in course of time. after a single addition of SO, the labile N7-guanines and N3-adenines were the major products at early time points. After 144 h of incubation at 37 degreesC, alphaN( The possible carcinogenicity of styrene is believed to be related to the DNA-binding properties of styrene 7,8-oxide (SO). In order to compare the intrinsic reactivity of the different nucleophilic sites in DNA towards SO and to evaluate the candidates for human biomonitoring we have determined the second-order rate constants and stabilities of several SO-adducts in double-stranded DNA. These include alpha- and beta -isomers of N7-substituted and alphaN(2)-substituted guanines, alpha- and beta N3-substituted and alphaN(6)-substitated adenines as well as beta N3- and alphaN(4)-substituted cytosines. The highest rate constants were found for the spontaneously depurinating N7-guanines being ca. 3-15-fold higher than those for the stable adducts. When the relative proportions of different alkylation products were determined in course of time. after a single addition of SO, the labile N7-guanines and N3-adenines were the major products at early time points. After 144 h of incubation at 37 degreesC, alphaN( (en)
Title	Kinetics of formation of specific styrene oxide adducts in double-stranded DNA Kinetics of formation of specific styrene oxide adducts in double-stranded DNA (en)
skos:prefLabel	Kinetics of formation of specific styrene oxide adducts in double-stranded DNA Kinetics of formation of specific styrene oxide adducts in double-stranded DNA (en)
skos:notation	RIV/00216208:11120/01:00003595!RIV12-GA0-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA313/99/1460), Z(AV0Z5039906)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Vodička, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	684283
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/01:00003595
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	biomonitoring; DNA adducts; styrene; styrene 7,8-oxide (en)
http://linked.open.../riv/klicoveSlovo	biomonitoring 8-oxide styrene 7 DNA adducts styrene
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[B1993B76E669]
http://linked.open...i/riv/nazevZdroje	Chemico-Biological Interactions
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanisms of genotoxic effects and prospects to the evaluation of individual susceptibility to styrene exposure
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	138
http://linked.open...iv/tvurceVysledku	Vodička, Pavel
http://linked.open...ain/vavai/riv/wos	000172366100001
http://linked.open...n/vavai/riv/zamer	The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy
issn	0009-2797
number of pages	24 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/S0009-2797(01)00254-X
http://localhost/t...ganizacniJednotka	11120

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