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Description
| - The possible carcinogenicity of styrene is believed to be related to the DNA-binding properties of styrene 7,8-oxide (SO). In order to compare the intrinsic reactivity of the different nucleophilic sites in DNA towards SO and to evaluate the candidates for human biomonitoring we have determined the second-order rate constants and stabilities of several SO-adducts in double-stranded DNA. These include alpha- and beta -isomers of N7-substituted and alphaN(2)-substituted guanines, alpha- and beta N3-substituted and alphaN(6)-substitated adenines as well as beta N3- and alphaN(4)-substituted cytosines. The highest rate constants were found for the spontaneously depurinating N7-guanines being ca. 3-15-fold higher than those for the stable adducts. When the relative proportions of different alkylation products were determined in course of time. after a single addition of SO, the labile N7-guanines and N3-adenines were the major products at early time points. After 144 h of incubation at 37 degreesC, alphaN(
- The possible carcinogenicity of styrene is believed to be related to the DNA-binding properties of styrene 7,8-oxide (SO). In order to compare the intrinsic reactivity of the different nucleophilic sites in DNA towards SO and to evaluate the candidates for human biomonitoring we have determined the second-order rate constants and stabilities of several SO-adducts in double-stranded DNA. These include alpha- and beta -isomers of N7-substituted and alphaN(2)-substituted guanines, alpha- and beta N3-substituted and alphaN(6)-substitated adenines as well as beta N3- and alphaN(4)-substituted cytosines. The highest rate constants were found for the spontaneously depurinating N7-guanines being ca. 3-15-fold higher than those for the stable adducts. When the relative proportions of different alkylation products were determined in course of time. after a single addition of SO, the labile N7-guanines and N3-adenines were the major products at early time points. After 144 h of incubation at 37 degreesC, alphaN( (en)
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Title
| - Kinetics of formation of specific styrene oxide adducts in double-stranded DNA
- Kinetics of formation of specific styrene oxide adducts in double-stranded DNA (en)
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skos:prefLabel
| - Kinetics of formation of specific styrene oxide adducts in double-stranded DNA
- Kinetics of formation of specific styrene oxide adducts in double-stranded DNA (en)
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skos:notation
| - RIV/00216208:11120/01:00003595!RIV12-GA0-11120___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA313/99/1460), Z(AV0Z5039906)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/01:00003595
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - biomonitoring; DNA adducts; styrene; styrene 7,8-oxide (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Chemico-Biological Interactions
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1016/S0009-2797(01)00254-X
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http://localhost/t...ganizacniJednotka
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