About: Cyclin A down-regulation in TGF beta 1-arrested follicular lymphoma cells

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Cyclin A down-regulation in TGF beta 1-arrested follicular lymphoma cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1006/excr.2000.5047
Description	Transforming growth factor beta1 (TGF beta1) induces growth arrest in many cell types, including B lymphocytes. We examined the effect of TGF on cell cycle progression of a non-Hodgkin lymphoma cell line of follicular lymphoma subtype (FL). After 48 h of TGF beta1 (10 ng/ml) treatment, a significantly increased number of DoHH2 cells was retained in G(0)/G(1) phase. We examined the level of cell cycle components, cyclins, cyclin-dependent kinases (cdk), and their inhibitors. We found that the expression of cyclin A and p21(WAF1) molecules was primarily modulated by TGF beta1 treatment while the expression of other regulatory components, like cyclins D, cyclin E, cdk2, cdk4, and cdk6 or p15(INK4B), p16(INK4A), and p27(KIP1) was not significantly affected. We further examined expression and activity of CREB/ATF family members to examine their roles in cyclin A inhibition. The binding activity of CREB-1 and ATF-8 to the CRE region of the cyclin A promoter was almost completely abolished due to the treatme Transforming growth factor beta1 (TGF beta1) induces growth arrest in many cell types, including B lymphocytes. We examined the effect of TGF on cell cycle progression of a non-Hodgkin lymphoma cell line of follicular lymphoma subtype (FL). After 48 h of TGF beta1 (10 ng/ml) treatment, a significantly increased number of DoHH2 cells was retained in G(0)/G(1) phase. We examined the level of cell cycle components, cyclins, cyclin-dependent kinases (cdk), and their inhibitors. We found that the expression of cyclin A and p21(WAF1) molecules was primarily modulated by TGF beta1 treatment while the expression of other regulatory components, like cyclins D, cyclin E, cdk2, cdk4, and cdk6 or p15(INK4B), p16(INK4A), and p27(KIP1) was not significantly affected. We further examined expression and activity of CREB/ATF family members to examine their roles in cyclin A inhibition. The binding activity of CREB-1 and ATF-8 to the CRE region of the cyclin A promoter was almost completely abolished due to the treatme (en)
Title	Cyclin A down-regulation in TGF beta 1-arrested follicular lymphoma cells Cyclin A down-regulation in TGF beta 1-arrested follicular lymphoma cells (en)
skos:prefLabel	Cyclin A down-regulation in TGF beta 1-arrested follicular lymphoma cells Cyclin A down-regulation in TGF beta 1-arrested follicular lymphoma cells (en)
skos:notation	RIV/00216208:11120/00:00003750!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(VS96129)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Müller, Julius Raška, Ivan Tvrdík, Daniel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	707862
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/00:00003750
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Growth-Factor-Beta; Mammary Epithelial-Cells; Element-Binding Protein; Barr-Virus Genes; Tgf-Beta; Transforming Growth-Factor-Beta-1; Retinoblastoma Protein; Dependent Kinases; Transcription Factor; Responsive Element (en)
http://linked.open.../riv/klicoveSlovo	Barr-Virus Genes Dependent Kinases Element-Binding Protein Growth-Factor-Beta Mammary Epithelial-Cells Responsive Element Retinoblastoma Protein Tgf-Beta Transcription Factor Transforming Growth-Factor-Beta-1
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[2FBD3511ED54]
http://linked.open...i/riv/nazevZdroje	Experimental Cell Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Laboratory of gene expression
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	261
http://linked.open...iv/tvurceVysledku	Raška, Ivan Tvrdík, Daniel Müller, Julius Djaborkhel, Rashed A.
http://linked.open...ain/vavai/riv/wos	000165622200027
issn	0014-4827
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1006/excr.2000.5047
http://localhost/t...ganizacniJednotka	11120

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software