About: Estrogen differentially alters NMDA- and kainate-induced seizures in prenatally morphine- and saline-exposed adult female rats

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About: Estrogen differentially alters NMDA- and kainate-induced seizures in prenatally morphine- and saline-exposed adult female rats Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/S0091-3057(00)00375-0
Description	The purpose of the present study was to investigate the effects of prenatal exposure to morphine on seizure susceptibility in adult female rats. Adult female rats, exposed to saline or morphine on prenatal days 11-18, were ovariectomized (OVX) and some were injected 48 h prior to seizure testing with estradiol benzoate (EB). To assess the latency to onset of stereotypy and seizures, females received systemic injections of N-methyl-D-aspartate (NMDA; 150, 175, 200 mg/kg) or kainic acid (KA; 10 or 15 mg/kg). Prenatal morphine exposure increased the latency to onset of wet-dog-shakes (WDS) in both OVX and OVX, EB-injected females after the higher dose of KA. However, prenatal morphine exposure increased the latency to onset of stereotypy only in OVX, EB-injected females after the highest dose of NMDA. Prenatal morphine exposure also increased the latency to onset of seizures after the lower dose of KA, but did not change the latency to onset of NMDA-induced seizures. Additionally, an EB injection increas The purpose of the present study was to investigate the effects of prenatal exposure to morphine on seizure susceptibility in adult female rats. Adult female rats, exposed to saline or morphine on prenatal days 11-18, were ovariectomized (OVX) and some were injected 48 h prior to seizure testing with estradiol benzoate (EB). To assess the latency to onset of stereotypy and seizures, females received systemic injections of N-methyl-D-aspartate (NMDA; 150, 175, 200 mg/kg) or kainic acid (KA; 10 or 15 mg/kg). Prenatal morphine exposure increased the latency to onset of wet-dog-shakes (WDS) in both OVX and OVX, EB-injected females after the higher dose of KA. However, prenatal morphine exposure increased the latency to onset of stereotypy only in OVX, EB-injected females after the highest dose of NMDA. Prenatal morphine exposure also increased the latency to onset of seizures after the lower dose of KA, but did not change the latency to onset of NMDA-induced seizures. Additionally, an EB injection increas (en)
Title	Estrogen differentially alters NMDA- and kainate-induced seizures in prenatally morphine- and saline-exposed adult female rats Estrogen differentially alters NMDA- and kainate-induced seizures in prenatally morphine- and saline-exposed adult female rats (en)
skos:prefLabel	Estrogen differentially alters NMDA- and kainate-induced seizures in prenatally morphine- and saline-exposed adult female rats Estrogen differentially alters NMDA- and kainate-induced seizures in prenatally morphine- and saline-exposed adult female rats (en)
skos:notation	RIV/00216208:11120/00:00003746!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 111200005)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Šlamberová, Romana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	710530
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/00:00003746
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NMDA; Kainic acid; Prenatal morphine; Estrogen (en)
http://linked.open.../riv/klicoveSlovo	Estrogen Kainic acid NMDA Prenatal morphine
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[2B0525821E06]
http://linked.open...i/riv/nazevZdroje	Pharmacology Biochemistry and Behavior
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	67
http://linked.open...iv/tvurceVysledku	Šlamberová, Romana Vathy, Ilona
http://linked.open...ain/vavai/riv/wos	000166163100015
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111200005
issn	0091-3057
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/S0091-3057(00)00375-0
http://localhost/t...ganizacniJednotka	11120

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