About: Prenatal morphine exposure alters N-methyl-D-aspartate- and kainate-induced seizures in adult male rats

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About: Prenatal morphine exposure alters N-methyl-D-aspartate- and kainate-induced seizures in adult male rats Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/S0091-3057(99)00185-9
Description	The purpose of the present study was to investigate whether prenatal exposure to morphine has effects on excitatory amino acid-induced seizures. Adult male rats, exposed on embryonic days 11-18 to saline or morphine, were injected with N-methyl-D-aspartate (NMDA) (150, 175, 200, 225, and 250 mg/kg) or kainic acid (KA) (15 or 20 mg/kg) in adulthood to assess the occurrence and latency to onset of stereotypy and seizures. The latency to onset of stereotypy was significantly increased after 175 mg/kg, and decreased after 200 mg/kg of NMDA in morphine-exposed animals. The lowest dose of NMDA (150 mg/kg) induced seizures in prenatally saline-treated control male rats but not in the morphine-exposed male rats. In the KA-injected group, prenatally morphine-exposed males had shorter latency to onset of wet-dog shakes, but there were no effects on the latency to onset of clonic seizures. The data suggest that prenatal morphine exposure has long-term effects on seizure susceptibility and the onset of stereotypy The purpose of the present study was to investigate whether prenatal exposure to morphine has effects on excitatory amino acid-induced seizures. Adult male rats, exposed on embryonic days 11-18 to saline or morphine, were injected with N-methyl-D-aspartate (NMDA) (150, 175, 200, 225, and 250 mg/kg) or kainic acid (KA) (15 or 20 mg/kg) in adulthood to assess the occurrence and latency to onset of stereotypy and seizures. The latency to onset of stereotypy was significantly increased after 175 mg/kg, and decreased after 200 mg/kg of NMDA in morphine-exposed animals. The lowest dose of NMDA (150 mg/kg) induced seizures in prenatally saline-treated control male rats but not in the morphine-exposed male rats. In the KA-injected group, prenatally morphine-exposed males had shorter latency to onset of wet-dog shakes, but there were no effects on the latency to onset of clonic seizures. The data suggest that prenatal morphine exposure has long-term effects on seizure susceptibility and the onset of stereotypy (en)
Title	Prenatal morphine exposure alters N-methyl-D-aspartate- and kainate-induced seizures in adult male rats Prenatal morphine exposure alters N-methyl-D-aspartate- and kainate-induced seizures in adult male rats (en)
skos:prefLabel	Prenatal morphine exposure alters N-methyl-D-aspartate- and kainate-induced seizures in adult male rats Prenatal morphine exposure alters N-methyl-D-aspartate- and kainate-induced seizures in adult male rats (en)
skos:notation	RIV/00216208:11120/00:00003744!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 111200005)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Velíšek, Libor Šlamberová, Romana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	722904
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/00:00003744
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Kainic acid; NMDA; Prenatal morphine; Seizures; Wet dog shakes (en)
http://linked.open.../riv/klicoveSlovo	Seizures Wet dog shakes Kainic acid NMDA Prenatal morphine
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D8A39C27E989]
http://linked.open...i/riv/nazevZdroje	Pharmacology Biochemistry and Behavior
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	65
http://linked.open...iv/tvurceVysledku	Šlamberová, Romana Velíšek, Libor Valthy, Ilona
http://linked.open...ain/vavai/riv/wos	000084394700008
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111200005
issn	0091-3057
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/S0091-3057(99)00185-9
http://localhost/t...ganizacniJednotka	11120

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