About: Expression of beta-catenins and cadherins by follicular dendritic cells in human lymph nodes

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About: Expression of beta-catenins and cadherins by follicular dendritic cells in human lymph nodes Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1078/0065-1281-00573
Description	n lymph nodes, dendritic cells form a complex meshwork and are linked by intercellular junctions. Intercellular junctions contribute to the integrity of lymphatic follicles and can potentially be affected by malignant processes in neighbouring B cells. We examined whether transmembrane molecules that constitute %22adherens junctions%22 are present in follicular dendritic cells of normal human lymph nodes. We found that follicular dendritic cells but not interdigitating dendritic cells or sinus lining cells expressed cadherin molecules. Follicular dendritic cells also expressed beta -catenin but not vinculin. The cadherin molecules, which were identified in situ with the use of a monoclonal pan-cadherin antibody, were not recognized by antibodies to E-cadherin, N-cadherin or beta -cadherin. Intrafollicularly, cadherins were clearly colocalized with beta -catenins, in a dot-like fashion. We also detected intrafollicular expression of desmogleins and desmosomal plaque proteins. These findings indic n lymph nodes, dendritic cells form a complex meshwork and are linked by intercellular junctions. Intercellular junctions contribute to the integrity of lymphatic follicles and can potentially be affected by malignant processes in neighbouring B cells. We examined whether transmembrane molecules that constitute %22adherens junctions%22 are present in follicular dendritic cells of normal human lymph nodes. We found that follicular dendritic cells but not interdigitating dendritic cells or sinus lining cells expressed cadherin molecules. Follicular dendritic cells also expressed beta -catenin but not vinculin. The cadherin molecules, which were identified in situ with the use of a monoclonal pan-cadherin antibody, were not recognized by antibodies to E-cadherin, N-cadherin or beta -cadherin. Intrafollicularly, cadherins were clearly colocalized with beta -catenins, in a dot-like fashion. We also detected intrafollicular expression of desmogleins and desmosomal plaque proteins. These findings indic (en)
Title	Expression of beta-catenins and cadherins by follicular dendritic cells in human lymph nodes Expression of beta-catenins and cadherins by follicular dendritic cells in human lymph nodes (en)
skos:prefLabel	Expression of beta-catenins and cadherins by follicular dendritic cells in human lymph nodes Expression of beta-catenins and cadherins by follicular dendritic cells in human lymph nodes (en)
skos:notation	RIV/00216208:11120/00:00003729!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(VS96129)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Müller, Julius Raška, Ivan Tvrdík, Daniel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	710991
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/00:00003729
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	follicular dendritic cells; adherens junctions; cadherins; beta-catenin; human; lymphatic follicle (en)
http://linked.open.../riv/klicoveSlovo	cadherins beta-catenin human adherens junctions lymphatic follicle follicular dendritic cells
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[B7AC95C1CA8F]
http://linked.open...i/riv/nazevZdroje	Acta Histochemica
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Laboratory of gene expression
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	102
http://linked.open...iv/tvurceVysledku	Raška, Ivan Tvrdík, Daniel Mandys, Václav Dvořák, Richard Müller, Julius Lojda, Zdeněk Djaborkhel, Rashed A. Bednář, Blahoslav
http://linked.open...ain/vavai/riv/wos	000165865000001
issn	0065-1281
number of pages	16 (xsd:int)
http://bibframe.org/vocab/doi	10.1078/0065-1281-00573
http://localhost/t...ganizacniJednotka	11120

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