About: High-dose immunosuppressive therapy with PBPC support in the treatment of poor risk multiple sclerosis

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About: High-dose immunosuppressive therapy with PBPC support in the treatment of poor risk multiple sclerosis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.nature.com/bmt/journal/v25/n5/pdf/1702180a.pdf
Description	High-dose immunoablative chemotherapy with autologous haematopoietic cell support might be beneficial in the treatment of intractable forms of MS. We mobilised PBPC in 11 patients with secondary progressive MS and finally eight patients were grafted after high-dose BEAM chemotherapy with either in vitro or in vivo T cell depletion. Median EDSS and SNRS scores at the time of inclusion were 6.5 (6.5-7.5) and 56 (44-65), respectively. PBPC mobilisation was safe with no serious adverse effects, and without significant aggravation of disability, One patient improved significantly (by 1.0 point on EDSS) after the mobilisation, Two mobilisation failures were observed. No life-threatening events occurred during the transplantation. All grafted patients, except one, at least stabilised their disability status. One patient improved significantly (by 1.5 points on EDSS), two patients improved slightly (by 0.5 points on EDSS), one patient worsened by 1.0 point on the EDSS in 10 months, High-dose immunoablative chemotherapy with autologous haematopoietic cell support might be beneficial in the treatment of intractable forms of MS. We mobilised PBPC in 11 patients with secondary progressive MS and finally eight patients were grafted after high-dose BEAM chemotherapy with either in vitro or in vivo T cell depletion. Median EDSS and SNRS scores at the time of inclusion were 6.5 (6.5-7.5) and 56 (44-65), respectively. PBPC mobilisation was safe with no serious adverse effects, and without significant aggravation of disability, One patient improved significantly (by 1.0 point on EDSS) after the mobilisation, Two mobilisation failures were observed. No life-threatening events occurred during the transplantation. All grafted patients, except one, at least stabilised their disability status. One patient improved significantly (by 1.5 points on EDSS), two patients improved slightly (by 0.5 points on EDSS), one patient worsened by 1.0 point on the EDSS in 10 months, (en)
Title	High-dose immunosuppressive therapy with PBPC support in the treatment of poor risk multiple sclerosis High-dose immunosuppressive therapy with PBPC support in the treatment of poor risk multiple sclerosis (en)
skos:prefLabel	High-dose immunosuppressive therapy with PBPC support in the treatment of poor risk multiple sclerosis High-dose immunosuppressive therapy with PBPC support in the treatment of poor risk multiple sclerosis (en)
skos:notation	RIV/00216208:11120/00:00003705!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kozák, Tomáš Piťha, Jiří Soukupová Maaloufová, Jacqueline
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	712412
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/00:00003705
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	multiple sclerosis; high-dose immunosuppressive therapy (en)
http://linked.open.../riv/klicoveSlovo	multiple sclerosis high-dose immunosuppressive therapy
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[56607AA3255D]
http://linked.open...i/riv/nazevZdroje	Bone Marrow Transplantation
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	25
http://linked.open...iv/tvurceVysledku	Kozák, Tomáš Piťha, Jiří Maaloufová, Jacqueline
http://linked.open...ain/vavai/riv/wos	000085743600012
issn	0268-3369
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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