About: Cytosolic calcium alterations in platelets of patients with early stages of Alzheimer's disease

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/s0197-4580(00)00166-4
Description	Alterations in calcium homeostasis might be implicated in the neuropathology of Alzheimer's disease (AD). To date it is not clear whether changes in cytosolic calcium level ([Ca2+](i)) are the result or the cause of pathogenic effects. In platelets of patients with early stages of AD, the basal values of [Ca2+](i) in the absence of extracellular Ca2+ were significantly lower in comparison with age-matched and young controls. After the addition of 1 mM calcium into the incubation medium the [Ca2+](i) markedly increased in platelets of AD patients whereas the increase only to a smaller extent was observed in control age-matched and young subjects. The present study proposes that calcium dysregulation during the whole disease period could not be uniform and according to our results the [Ca2+](i) is reduced in the first stages of AD. We suggest that the disturbed calcium homeostasis in AD is an %22early defect. Alterations in calcium homeostasis might be implicated in the neuropathology of Alzheimer's disease (AD). To date it is not clear whether changes in cytosolic calcium level ([Ca2+](i)) are the result or the cause of pathogenic effects. In platelets of patients with early stages of AD, the basal values of [Ca2+](i) in the absence of extracellular Ca2+ were significantly lower in comparison with age-matched and young controls. After the addition of 1 mM calcium into the incubation medium the [Ca2+](i) markedly increased in platelets of AD patients whereas the increase only to a smaller extent was observed in control age-matched and young subjects. The present study proposes that calcium dysregulation during the whole disease period could not be uniform and according to our results the [Ca2+](i) is reduced in the first stages of AD. We suggest that the disturbed calcium homeostasis in AD is an %22early defect. (en)
Title	Cytosolic calcium alterations in platelets of patients with early stages of Alzheimer's disease Cytosolic calcium alterations in platelets of patients with early stages of Alzheimer's disease (en)
skos:prefLabel	Cytosolic calcium alterations in platelets of patients with early stages of Alzheimer's disease Cytosolic calcium alterations in platelets of patients with early stages of Alzheimer's disease (en)
skos:notation	RIV/00216208:11120/00:00003620!RIV12-MZ0-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NG15), Z(MSM 111100001), Z(MSM 113100003)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Höschl, Cyril
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	707911
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/00:00003620
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Alzheimer´s disease; Early stages; Platelets; Cytosolic calcium (en)
http://linked.open.../riv/klicoveSlovo	Alzheimer´s disease Cytosolic calcium Early stages Platelets
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[CC1D641DE2CB]
http://linked.open...i/riv/nazevZdroje	Neurobiology of Aging
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomarkers of Alzheimer's disease.
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Höschl, Cyril Řípová, Daniela
http://linked.open...ain/vavai/riv/wos	000089271200014
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20113100003 http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111100001
issn	0197-4580
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/s0197-4580(00)00166-4
http://localhost/t...ganizacniJednotka	11120

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