About: Biocompatibility of HEMA Copolymers Designed for Treatment of CNS Diseases with Polymer-Encapsulated Cells

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About: Biocompatibility of HEMA Copolymers Designed for Treatment of CNS Diseases with Polymer-Encapsulated Cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1021/bp000113m
Description	Surrounding the cells with a semipermeable polymeric membrane allows transplanting unmatched xenogeneic cells without a risk of their rejection. We prepared and tested several 2-hydroxyethyl methacrylate (HEMA) copolymers with alkyl methacrylates or acrylates to find out which was the most valuable for cell encapsulation. On the basis of optimum physical properties and good results of cytotoxicity tests, HEMA-EMA copolymer was chosen as a suitable candidate for encapsulation and immunoprotection of xenogeneic cells before their grafting into the central nervous system (CNS). To characterize the biocompatibility of p(HEMA-co-EMA) copolymer in the CNS, we implanted microcapsules made of this hydrogel into the brains of adult rats that were allowed to survive for 0.5, 1, 3, 6, and 9 months. Analysis of histological sections containing the implantation site was aimed at assessment of the cellular density at the implant-brain interface and identification of cell types participating in a tissue reaction. Surrounding the cells with a semipermeable polymeric membrane allows transplanting unmatched xenogeneic cells without a risk of their rejection. We prepared and tested several 2-hydroxyethyl methacrylate (HEMA) copolymers with alkyl methacrylates or acrylates to find out which was the most valuable for cell encapsulation. On the basis of optimum physical properties and good results of cytotoxicity tests, HEMA-EMA copolymer was chosen as a suitable candidate for encapsulation and immunoprotection of xenogeneic cells before their grafting into the central nervous system (CNS). To characterize the biocompatibility of p(HEMA-co-EMA) copolymer in the CNS, we implanted microcapsules made of this hydrogel into the brains of adult rats that were allowed to survive for 0.5, 1, 3, 6, and 9 months. Analysis of histological sections containing the implantation site was aimed at assessment of the cellular density at the implant-brain interface and identification of cell types participating in a tissue reaction. (en)
Title	Biocompatibility of HEMA Copolymers Designed for Treatment of CNS Diseases with Polymer-Encapsulated Cells Biocompatibility of HEMA Copolymers Designed for Treatment of CNS Diseases with Polymer-Encapsulated Cells (en)
skos:prefLabel	Biocompatibility of HEMA Copolymers Designed for Treatment of CNS Diseases with Polymer-Encapsulated Cells Biocompatibility of HEMA Copolymers Designed for Treatment of CNS Diseases with Polymer-Encapsulated Cells (en)
skos:notation	RIV/00216208:11120/00:00003600!RIV12-GA0-11120___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA304/98/0267)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Dvořánková, Barbora
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	705669
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/00:00003600
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Parkinsons Disease; Secreting Fibroblasts; Transplantation; Rat; Protein; Tissue; Culture (en)
http://linked.open.../riv/klicoveSlovo	Culture Tissue Protein Rat Parkinsons Disease Secreting Fibroblasts Transplantation
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[2C85374170B9]
http://linked.open...i/riv/nazevZdroje	Biotechnology Progress
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Encapsulation of neural mammalian cells for treatment of neurodegenerative diseases
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Dvořánková, Barbora Mokrý, Jaroslav
http://linked.open...ain/vavai/riv/wos	000089797600033
issn	8756-7938
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1021/bp000113m
http://localhost/t...ganizacniJednotka	11120

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