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  • Rationale: Previous respiratory diseases have been associated with increased risk of lung cancer. Respiratory conditions often co-occur and few studies have investigated multiple conditions simultaneously. Objectives: Investigate lung cancer risk associated with chronic bronchitis, emphysema, tuberculosis, pneumonia, and asthma. Methods: The SYNERGY project pooled information on previous respiratory diseases from 12,739 case subjects and 14,945 control subjects from 7 case-control studies conducted in Europe and Canada. Multivariate logistic regression models were used to investigate the relationship between individual diseases adjusting for co-occurring conditions, and patterns of respiratory disease diagnoses and lung cancer. Analyses were stratified by sex, and adjusted for age, center, ever-employed in a high-risk occupation, education, smoking status, cigarette pack-years, and time since quitting smoking. Measurements and Main Results: Chronic bronchitis and emphysema were positively associated with lung cancer, after accounting for other respiratory diseases and smoking (e.g., in men: odds ratio [On 1.33; 95% confidence interval [CI], 1.20-1.48 and OR, 1.50; 95% CI, 1.21-1.87, respectively). A positive relationship was observed between. lung cancer and pneumonia diagnosed 2 years or less before lung cancer (OR, 3.31; 95% CI, 2.33-4.70 for men), but not longer. Co-occurrence of chronic bronchitis and emphysema and/or pneumonia had a stronger positive association with lung cancer than chronic bronchitis %22only.%22 Asthma had an inverse association with lung cancer, the association being stronger with an asthma diagnosis 5 years or more before lung cancer compared with shorter. Conclusions: Findings from this large international case-control consortium indicate that after accounting for co-occurring respiratory diseases, chronic bronchitis and emphysema continue to have a positive association with lung cancer.
  • Rationale: Previous respiratory diseases have been associated with increased risk of lung cancer. Respiratory conditions often co-occur and few studies have investigated multiple conditions simultaneously. Objectives: Investigate lung cancer risk associated with chronic bronchitis, emphysema, tuberculosis, pneumonia, and asthma. Methods: The SYNERGY project pooled information on previous respiratory diseases from 12,739 case subjects and 14,945 control subjects from 7 case-control studies conducted in Europe and Canada. Multivariate logistic regression models were used to investigate the relationship between individual diseases adjusting for co-occurring conditions, and patterns of respiratory disease diagnoses and lung cancer. Analyses were stratified by sex, and adjusted for age, center, ever-employed in a high-risk occupation, education, smoking status, cigarette pack-years, and time since quitting smoking. Measurements and Main Results: Chronic bronchitis and emphysema were positively associated with lung cancer, after accounting for other respiratory diseases and smoking (e.g., in men: odds ratio [On 1.33; 95% confidence interval [CI], 1.20-1.48 and OR, 1.50; 95% CI, 1.21-1.87, respectively). A positive relationship was observed between. lung cancer and pneumonia diagnosed 2 years or less before lung cancer (OR, 3.31; 95% CI, 2.33-4.70 for men), but not longer. Co-occurrence of chronic bronchitis and emphysema and/or pneumonia had a stronger positive association with lung cancer than chronic bronchitis %22only.%22 Asthma had an inverse association with lung cancer, the association being stronger with an asthma diagnosis 5 years or more before lung cancer compared with shorter. Conclusions: Findings from this large international case-control consortium indicate that after accounting for co-occurring respiratory diseases, chronic bronchitis and emphysema continue to have a positive association with lung cancer. (en)
Title
  • Is Previous Respiratory Disease a Risk Factor for Lung Cancer?
  • Is Previous Respiratory Disease a Risk Factor for Lung Cancer? (en)
skos:prefLabel
  • Is Previous Respiratory Disease a Risk Factor for Lung Cancer?
  • Is Previous Respiratory Disease a Risk Factor for Lung Cancer? (en)
skos:notation
  • RIV/00216208:11110/14:10285641!RIV15-MSM-11110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, N
http://linked.open...iv/cisloPeriodika
  • 5
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http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 22904
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11110/14:10285641
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • case-control study; data pooling; pulmonary disease; lung neoplasm; epidemiologic study (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [1F2948DAA9FD]
http://linked.open...i/riv/nazevZdroje
  • American Journal of Respiratory and Critical Care Medicine
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 190
http://linked.open...iv/tvurceVysledku
  • Bencko, Vladimír
  • Peters, Susan
  • Vermeulen, R.
  • Boffetta, Paolo
  • Brenner, Darren R.
  • Foretova, Lenka
  • Janout, Vladimir
  • Zaridze, David
  • Stuecker, Isabelle
  • Ahrens, Wolfgang
  • Brueske, Irene
  • Caporaso, Neil
  • Demers, Paul
  • Dumitru, Rodica Stanescu
  • Fabianova, Eleonora
  • Guida, Florence
  • Kendzia, Benjamin
  • Landi, Maria Teresa
  • Lissowska, Jolanta
  • McLaughlin, John
  • Pohlabeln, Hermann
  • Rudnai, Peter
  • Schuez, Joachim
  • Siemiatycki, Jack
  • Szeszenia-Dabrowska, Neonila
  • Wichmann, Heinz-Erich
  • Olsson, A. C.
  • Behrens, T.
  • Field, John K.
  • Bruning, T.
  • De Matteis, Sara
  • Denholm, Rachel
  • Joecke, Karl-Heinz I.
  • Kromhout, H.
  • Straif, Kurt
http://linked.open...ain/vavai/riv/wos
  • 000341554400010
issn
  • 1073-449X
number of pages
http://bibframe.org/vocab/doi
  • 10.1164/rccm.201402-0338OC
http://localhost/t...ganizacniJednotka
  • 11110
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