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  • Tobacco addiction is a serious psychosocial and health problem. A pregnant woman who smokes not only influences the maternal organism, but also passes health risks on to the unborn child. A fetus exposed to maternal smoking is not only directly influenced, but is also endangered by a wide range of diseases up to his or her adult years. The components of tobacco smoke play a significant role in the development of a number of diseases for a large proportion of the smoking population, as well as among those pregnant. This article summarizes findings regarding the impacts on the production of steroid hormones - first describing the smoking-related changes in steroidogenesis in women, and then focusing on the influence of maternal smoking on the fetus's developing steroidogenesis. We assume that if during prenatal development the fetus has already been exposed to the effect of endocrine disruptors at the time fetal steroidogenesis begins fetal programming, this exposure can have serious pathophysiological effects both in the pregnancy as well as later in life. An example of such effects might be a delay in the creation of kidney adrenal androgens, which could also be evident on the level of steroid neuroactive metabolites that may influence the individual's psychological state and lead to later addictions. (C) 2013 Published by Elsevier Ltd.
  • Tobacco addiction is a serious psychosocial and health problem. A pregnant woman who smokes not only influences the maternal organism, but also passes health risks on to the unborn child. A fetus exposed to maternal smoking is not only directly influenced, but is also endangered by a wide range of diseases up to his or her adult years. The components of tobacco smoke play a significant role in the development of a number of diseases for a large proportion of the smoking population, as well as among those pregnant. This article summarizes findings regarding the impacts on the production of steroid hormones - first describing the smoking-related changes in steroidogenesis in women, and then focusing on the influence of maternal smoking on the fetus's developing steroidogenesis. We assume that if during prenatal development the fetus has already been exposed to the effect of endocrine disruptors at the time fetal steroidogenesis begins fetal programming, this exposure can have serious pathophysiological effects both in the pregnancy as well as later in life. An example of such effects might be a delay in the creation of kidney adrenal androgens, which could also be evident on the level of steroid neuroactive metabolites that may influence the individual's psychological state and lead to later addictions. (C) 2013 Published by Elsevier Ltd. (en)
Title
  • The effects of smoking on steroid metabolism and fetal programming
  • The effects of smoking on steroid metabolism and fetal programming (en)
skos:prefLabel
  • The effects of smoking on steroid metabolism and fetal programming
  • The effects of smoking on steroid metabolism and fetal programming (en)
skos:notation
  • RIV/00216208:11110/14:10285096!RIV15-MSM-11110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • January
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 13771
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11110/14:10285096
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Steroidogenesis; Pregnancy; Women; Smoking (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [7E2FBFFF0A87]
http://linked.open...i/riv/nazevZdroje
  • Journal of Steroid Biochemistry and Molecular Biology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 139
http://linked.open...iv/tvurceVysledku
  • Dušková, Michaela
  • Hruškovičová, Hana
  • Pařízek, Antonín
  • Stárka, L.
  • Šimůnková, K.
http://linked.open...ain/vavai/riv/wos
  • 000329599300019
issn
  • 0960-0760
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.jsbmb.2013.05.003
http://localhost/t...ganizacniJednotka
  • 11110
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