About: Transcriptional and epigenetic regulation in the development of myeloid cells: normal and diseased myelopoiesis

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Transcriptional and epigenetic regulation in the development of myeloid cells: normal and diseased myelopoiesis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Myeloid cells constitute the innate arm of the vertebrate immune system and arise from haematopoietic stem cells being committed to their cell fate through a series of lineage restrictions regulated by a gene regulatory network. This gene network consists of transcription factors as well as components of the epigenetic machinery that, in cooperation with one another, will programme progenitors to adopt and differentiate along a certain lineage programme. By virtue of their obligatory function, dysregulation in the activity of these regulatory factors can contribute to the pathogenesis of myeloid leukaemias. To understand the molecular aetiology of myeloid dysplasias it is imperative to first study and model the network that regulates normal development. Equipped with this crucial understanding we can then begin to decipher what, how and why things have gone wrong in the pathology of myeloid leukaemias. Myeloid cells constitute the innate arm of the vertebrate immune system and arise from haematopoietic stem cells being committed to their cell fate through a series of lineage restrictions regulated by a gene regulatory network. This gene network consists of transcription factors as well as components of the epigenetic machinery that, in cooperation with one another, will programme progenitors to adopt and differentiate along a certain lineage programme. By virtue of their obligatory function, dysregulation in the activity of these regulatory factors can contribute to the pathogenesis of myeloid leukaemias. To understand the molecular aetiology of myeloid dysplasias it is imperative to first study and model the network that regulates normal development. Equipped with this crucial understanding we can then begin to decipher what, how and why things have gone wrong in the pathology of myeloid leukaemias. (en)
Title	Transcriptional and epigenetic regulation in the development of myeloid cells: normal and diseased myelopoiesis Transcriptional and epigenetic regulation in the development of myeloid cells: normal and diseased myelopoiesis (en)
skos:prefLabel	Transcriptional and epigenetic regulation in the development of myeloid cells: normal and diseased myelopoiesis Transcriptional and epigenetic regulation in the development of myeloid cells: normal and diseased myelopoiesis (en)
skos:notation	RIV/00216208:11110/14:10283651!RIV15-MSM-11110___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0109), P(GAP305/12/1033), S
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Stopka, Tomáš
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	50982
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/14:10283651
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	EZH2; DNMT3A; IDH1/2; TET2; MLL; RARα; GATA-2; RUNX1; C/EBPA; PU.1; APL; CML; MDS; AML; Leukaemia; Differentiation; LSC; HSC; Gene Network; Myeloid; pigenetics; Transcription factor (en)
http://linked.open.../riv/klicoveSlovo	RARα CML PU.1 RUNX1 AML C/EBPA EZH2 GATA-2 Gene Network LSC Myeloid pigenetics MLL Transcription factor Differentiation HSC MDS APL IDH1/2 Leukaemia DNMT3A TET2
http://linked.open...ontrolniKodProRIV	[C7F4EE789617]
http://linked.open...i/riv/mistoVydani	Heidelberg
http://linked.open...vEdiceCisloSvazku	Epigenetics and Human Health
http://linked.open...i/riv/nazevZdroje	Epigenetics and Human Health
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...v/pocetStranKnihy	416 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University Regulation of hematopoietic stem cell differentiation by chromatin remodeling SWI/SNF2 ATPase Smarca5 (Snf2h) in mouse.
http://linked.open...UplatneniVysledku	2014
http://linked.open...iv/tvurceVysledku	Stopka, Tomáš Laslo, Peter
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/978-3-642-45198-0_9
http://purl.org/ne...btex#hasPublisher	Springer-Verlag. (Berlin; Heidelberg)
https://schema.org/isbn	978-3-642-45197-3
http://localhost/t...ganizacniJednotka	11110

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software