About: Monodisperse Carboxyl-Functionalized Poly(Ethylene Glycol)-Coated Magnetic Poly(Glycidyl Methacrylate) Microspheres: Application to the Immunocapture of beta-Amyloid Peptides

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About: Monodisperse Carboxyl-Functionalized Poly(Ethylene Glycol)-Coated Magnetic Poly(Glycidyl Methacrylate) Microspheres: Application to the Immunocapture of beta-Amyloid Peptides Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1002/mabi.201400249
Description	Identification and evaluation of small changes in beta-amyloid peptide (A beta) levels in cerebrospinal fluid is of crucial importance for early detection of Alzheimer's disease. Microfluidic detection methods enable effective preconcentration of Ab using magnetic microparticles coated with Ab antibodies. Poly-(glycidyl methacrylate) microspheres are coated with alpha-amino-omega-methoxy-PEG(5000)/alpha-amino-omega-Boc-NH-PEG(5000) Boc groups deprotected and NH2 succinylated to introduce carboxyl groups. Capillary electrophoresis with laser-induced fluorescence detection confirms the efficient capture of A beta 1-40 peptides on the microspheres with immobilized monoclonal anti-A beta 6E10. The capture specificity is confirmed by comparing A beta 1-40 levels on the anti-IgG-immobilized particles used as a control. Identification and evaluation of small changes in beta-amyloid peptide (A beta) levels in cerebrospinal fluid is of crucial importance for early detection of Alzheimer's disease. Microfluidic detection methods enable effective preconcentration of Ab using magnetic microparticles coated with Ab antibodies. Poly-(glycidyl methacrylate) microspheres are coated with alpha-amino-omega-methoxy-PEG(5000)/alpha-amino-omega-Boc-NH-PEG(5000) Boc groups deprotected and NH2 succinylated to introduce carboxyl groups. Capillary electrophoresis with laser-induced fluorescence detection confirms the efficient capture of A beta 1-40 peptides on the microspheres with immobilized monoclonal anti-A beta 6E10. The capture specificity is confirmed by comparing A beta 1-40 levels on the anti-IgG-immobilized particles used as a control. (en)
Title	Monodisperse Carboxyl-Functionalized Poly(Ethylene Glycol)-Coated Magnetic Poly(Glycidyl Methacrylate) Microspheres: Application to the Immunocapture of beta-Amyloid Peptides Monodisperse Carboxyl-Functionalized Poly(Ethylene Glycol)-Coated Magnetic Poly(Glycidyl Methacrylate) Microspheres: Application to the Immunocapture of beta-Amyloid Peptides (en)
skos:prefLabel	Monodisperse Carboxyl-Functionalized Poly(Ethylene Glycol)-Coated Magnetic Poly(Glycidyl Methacrylate) Microspheres: Application to the Immunocapture of beta-Amyloid Peptides Monodisperse Carboxyl-Functionalized Poly(Ethylene Glycol)-Coated Magnetic Poly(Glycidyl Methacrylate) Microspheres: Application to the Immunocapture of beta-Amyloid Peptides (en)
skos:notation	RIV/00216208:11110/14:10283560!RIV15-MSM-11110___
http://linked.open...avai/riv/aktivita	I P R
http://linked.open...avai/riv/aktivity	I, P(7E12053), R
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Kučerová, Zdenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	30460
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/14:10283560
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	microspheres; magnetic; functionalization; CE-LIF detection; beta-amyloid peptides (en)
http://linked.open.../riv/klicoveSlovo	CE-LIF detection beta-amyloid peptides functionalization magnetic microspheres
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[8D39CCE64084]
http://linked.open...i/riv/nazevZdroje	Macromolecular Bioscience
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Nanosystems for early Diagnosis of Neurodegenerative Diseases
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Kučerová, Zdenka Taverna, Myriam Hlidkova, Helena Horak, Daniel Proks, Vladimir Hiraoui, Mohamed Mazl Chanova, Eliska Smadja, Claire
http://linked.open...ain/vavai/riv/wos	000344749200009
issn	1616-5187
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/mabi.201400249
http://localhost/t...ganizacniJednotka	11110

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