About: Mitochondrial membrane assembly of TMEM70 protein

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.mito.2014.02.010
Description	Dysfunction of TMEM70 disrupts the biogenesis of ATP synthase and represents the frequent cause of autosomal recessive encephalocardiomyopathy. We used tagged forms of TMEM70 and demonstrated that it has a hairpin structure with the N- and C-termini oriented towards the mitochondrial matrix. On BN-PAGE TMEM70 was detected in multiple forms including dimers and displayed partial overlap with assembled ATP synthase. Immunoprecipitation studies confirmed mutual interactions between TMEM70 molecules but, together with immunogold electron microscopy, not direct interaction with ATP synthase subunits. This indicates that the biological function of TMEM70 in the ATP synthase biogenesis may be mediated through interaction with other protein(s). Dysfunction of TMEM70 disrupts the biogenesis of ATP synthase and represents the frequent cause of autosomal recessive encephalocardiomyopathy. We used tagged forms of TMEM70 and demonstrated that it has a hairpin structure with the N- and C-termini oriented towards the mitochondrial matrix. On BN-PAGE TMEM70 was detected in multiple forms including dimers and displayed partial overlap with assembled ATP synthase. Immunoprecipitation studies confirmed mutual interactions between TMEM70 molecules but, together with immunogold electron microscopy, not direct interaction with ATP synthase subunits. This indicates that the biological function of TMEM70 in the ATP synthase biogenesis may be mediated through interaction with other protein(s). (en)
Title	Mitochondrial membrane assembly of TMEM70 protein Mitochondrial membrane assembly of TMEM70 protein (en)
skos:prefLabel	Mitochondrial membrane assembly of TMEM70 protein Mitochondrial membrane assembly of TMEM70 protein (en)
skos:notation	RIV/00216208:11110/14:10283206!RIV15-MSM-11110___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GAP303/11/0970), P(GB14-36804G), P(LL1204), S
http://linked.open...iv/cisloPeriodika	February
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Kratochvílová, Hana Cmarko, Dušan Hejzlarová, Kateřina Zeman, Jiří Tesařová, Markéta Gombitová, Adriána
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	29559
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/14:10283206
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Biogenesis; TMEM70; ATP synthase; Mitochondria (en)
http://linked.open.../riv/klicoveSlovo	ATP synthase TMEM70 Biogenesis Mitochondria
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[A5AB90338A2F]
http://linked.open...i/riv/nazevZdroje	Mitochondrion
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanism of ATP synthase biogenesis and the role of TMEM70 protein Genetic analysis of mitochondrial proteome: Integration of mitochondrial-nuclear epistasis with disease phenotypes in the rat Centrum mitochondriální biologie a patologie (MITOCENTRUM)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Houštěk, Josef Kratochvílová, Hana Vrbacký, Marek Hejzlarová, Kateřina Tesařová, Markéta Zeman, Jiří Cmarko, Dušan Mráček, Tomáš Gombitová, Adriána Karbanová, Vendula Wittig, Ilka
http://linked.open...ain/vavai/riv/wos	000336009600001
issn	1567-7249
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.mito.2014.02.010
http://localhost/t...ganizacniJednotka	11110

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