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Description
  • Connexin40 (Cx40) is the main connexin expressed in the murine atria and ventricular conduction system. We assess here the developmental role of Cx40 in atrial conduction of the mouse. Cx40 deficiency significantly prolonged activation times in embryonic day 10.5, 12.5 and 14.5 atria during spontaneous activation; the severity decreased with increasing age. In a majority of Cx40 deficient mice the impulse originated from an ectopic focus in the right atrial appendage; in such a case the activation time was even longer due to prolonged activation. Cx40 has thus an important physiological role in the developing atria.
  • Connexin40 (Cx40) is the main connexin expressed in the murine atria and ventricular conduction system. We assess here the developmental role of Cx40 in atrial conduction of the mouse. Cx40 deficiency significantly prolonged activation times in embryonic day 10.5, 12.5 and 14.5 atria during spontaneous activation; the severity decreased with increasing age. In a majority of Cx40 deficient mice the impulse originated from an ectopic focus in the right atrial appendage; in such a case the activation time was even longer due to prolonged activation. Cx40 has thus an important physiological role in the developing atria. (en)
Title
  • The role of connexin40 in developing atrial conduction
  • The role of connexin40 in developing atrial conduction (en)
skos:prefLabel
  • The role of connexin40 in developing atrial conduction
  • The role of connexin40 in developing atrial conduction (en)
skos:notation
  • RIV/00216208:11110/14:10272151!RIV15-MSM-11110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(GA13-12412S), P(GAP302/11/1308), P(GD204/09/H084), S
http://linked.open...iv/cisloPeriodika
  • 8
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 43091
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11110/14:10272151
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Mouse embryo; Optical mapping; Sinoatrial node; Arrhythmogenesis; Heart development (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [48D9F781C68F]
http://linked.open...i/riv/nazevZdroje
  • FEBS Letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 588
http://linked.open...iv/tvurceVysledku
  • Beneš, Jiří
  • Sedmera, David
  • Krejčí, Eliška
  • Šaňková, Barbora
  • Kvasilová, Alena
  • Ammirabile, Grazia
  • Campione, Marina
http://linked.open...ain/vavai/riv/wos
  • 000334317600035
issn
  • 0014-5793
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.febslet.2014.01.032
http://localhost/t...ganizacniJednotka
  • 11110
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