About: Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development

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About: Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1371/journal.pmed.1001551
Description	Background: Endometrial cancer incidence is continuing to rise in the wake of the current ageing and obesity epidemics. Much of the risk for endometrial cancer development is influenced by the environment and lifestyle. Accumulating evidence suggests that the epigenome serves as the interface between the genome and the environment and that hypermethylation of stem cell polycomb group target genes is an epigenetic hallmark of cancer. The objective of this study was to determine the functional role of epigenetic factors in endometrial cancer development. Background: Endometrial cancer incidence is continuing to rise in the wake of the current ageing and obesity epidemics. Much of the risk for endometrial cancer development is influenced by the environment and lifestyle. Accumulating evidence suggests that the epigenome serves as the interface between the genome and the environment and that hypermethylation of stem cell polycomb group target genes is an epigenetic hallmark of cancer. The objective of this study was to determine the functional role of epigenetic factors in endometrial cancer development. (en)
Title	Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development (en)
skos:prefLabel	Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development (en)
skos:notation	RIV/00216208:11110/13:10195292!RIV15-MSM-11110___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(7E13033)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Zikán, Michal Cibula, David
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	103304
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/13:10195292
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CARCINOMA; RECEPTORS; MUTATIONS; EXPRESSION; IMPLANTATION; GENES; PATHWAYS; HYPERMETHYLATION; PROGESTERONE; CELL SIGNATURE (en)
http://linked.open.../riv/klicoveSlovo	RECEPTORS EXPRESSION MUTATIONS CELL SIGNATURE HYPERMETHYLATION IMPLANTATION PATHWAYS PROGESTERONE CARCINOMA GENES
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[A108A978E39E]
http://linked.open...i/riv/nazevZdroje	PLoS Medicine [online]
http://linked.open...in/vavai/riv/obor	FK
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	22 (xsd:int)
http://linked.open...vavai/riv/projekt	Epigenetics for female personalized cancer care
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Cibula, David Zikán, Michal Jones, A. Li, Q. Hayward, J. D. Kannan, A. Moud, T. Teschendorf, A. E. West, J.
http://linked.open...ain/vavai/riv/wos	000330371600008
issn	1549-1676
number of pages	15 (xsd:int)
http://bibframe.org/vocab/doi	10.1371/journal.pmed.1001551
http://localhost/t...ganizacniJednotka	11110

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