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  • This paper reviews the impact of genetic variability of drug metabolizing enzymes, transporters, receptors, and pathways involved in chronic pain perception on the efficacy and safety of analgesics and other drugs used for chronic pain treatment. Several candidate genes have been identified in the literature, while there is usually only limited clinical evidence substantiating for the penetration of the testing for these candidate biomarkers into the clinical practice. Further, the pain-perception regulation and modulation are still not fully understood, and thus more complex knowledge of genetic and epigenetic background for analgesia will be needed prior to the clinical use of the candidate genetic biomarkers.
  • This paper reviews the impact of genetic variability of drug metabolizing enzymes, transporters, receptors, and pathways involved in chronic pain perception on the efficacy and safety of analgesics and other drugs used for chronic pain treatment. Several candidate genes have been identified in the literature, while there is usually only limited clinical evidence substantiating for the penetration of the testing for these candidate biomarkers into the clinical practice. Further, the pain-perception regulation and modulation are still not fully understood, and thus more complex knowledge of genetic and epigenetic background for analgesia will be needed prior to the clinical use of the candidate genetic biomarkers. (en)
Title
  • Pharmacogenetics of Chronic Pain and Its Treatment
  • Pharmacogenetics of Chronic Pain and Its Treatment (en)
skos:prefLabel
  • Pharmacogenetics of Chronic Pain and Its Treatment
  • Pharmacogenetics of Chronic Pain and Its Treatment (en)
skos:notation
  • RIV/00216208:11110/13:10195055!RIV14-MZ0-11110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(NT11324)
http://linked.open...iv/cisloPeriodika
  • 2013
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 95994
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11110/13:10195055
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • tumor-necrosis-factor; p-glycoprotein inhibition; single-nucleotide polymorphism; serotonin transporter gene; nonsteroidal antiinflammatory drugs; opioid receptor gene; blood-brain-barrier; catechol-o-methyltransferase (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [CCF90EAD2164]
http://linked.open...i/riv/nazevZdroje
  • Mediators of Inflammation
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • Neuveden
http://linked.open...iv/tvurceVysledku
  • Slanař, Ondřej
  • Matoušková, Olga
  • Světlík, Svatopluk
  • Bakhouche, Hana
  • Hronová, Karolína
http://linked.open...ain/vavai/riv/wos
  • 000319931000001
issn
  • 0962-9351
number of pages
http://bibframe.org/vocab/doi
  • 10.1155/2013/864319
http://localhost/t...ganizacniJednotka
  • 11110
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