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  • The chapter summarizes information on the pathophysiology of mood disorders and biochemical mechanisms of action of antidepressants and mood stabilizers with focus on an endocannabinoid regulation of monoamines in depression and bipolar disorder. Leading role in neurochemistry and pathophysiology of mood disorders could be awarded to disturbed monoamine neurotransmission, dysfunction in energy metabolism of neurons, modulation of inflammatory and neuroendocrine pathways, and changes in activities of transcription factors, neurotrophic factors and other components involved in neuroplasticity. A role of endocannabinoid system in pathophysiology of mood disorders is supposed, but little known. In the light of new findings, there is potential for pharmacological regulation of endocannabinoid system in treatment of depressive and bipolar disorder.
  • The chapter summarizes information on the pathophysiology of mood disorders and biochemical mechanisms of action of antidepressants and mood stabilizers with focus on an endocannabinoid regulation of monoamines in depression and bipolar disorder. Leading role in neurochemistry and pathophysiology of mood disorders could be awarded to disturbed monoamine neurotransmission, dysfunction in energy metabolism of neurons, modulation of inflammatory and neuroendocrine pathways, and changes in activities of transcription factors, neurotrophic factors and other components involved in neuroplasticity. A role of endocannabinoid system in pathophysiology of mood disorders is supposed, but little known. In the light of new findings, there is potential for pharmacological regulation of endocannabinoid system in treatment of depressive and bipolar disorder. (en)
Title
  • Pathophysiology of Mood Disorders and Mechanisms of Action of Antidepressants and Mood Stabilizers
  • Pathophysiology of Mood Disorders and Mechanisms of Action of Antidepressants and Mood Stabilizers (en)
skos:prefLabel
  • Pathophysiology of Mood Disorders and Mechanisms of Action of Antidepressants and Mood Stabilizers
  • Pathophysiology of Mood Disorders and Mechanisms of Action of Antidepressants and Mood Stabilizers (en)
skos:notation
  • RIV/00216208:11110/13:10193047!RIV14-MSM-11110___
http://linked.open...avai/riv/aktivita
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  • I, Z(MSM0021620849)
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  • 95512
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  • RIV/00216208:11110/13:10193047
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  • cannabinoids; mood stabilizers; antidepressants; Mood disorders (en)
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  • [8869AB6C2B48]
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  • New York
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  • Neuveden
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  • Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders
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  • Fišar, Zdeněk
http://linked.open...n/vavai/riv/zamer
number of pages
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  • 10.1007/978-1-4614-7940-6_6
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  • Springer-Verlag
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  • 978-1-4614-7939-0
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  • 11110
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