About: Fine tuning of the pH-dependent drug release rate from polyHPMA-ellipticinium conjugates

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About: Fine tuning of the pH-dependent drug release rate from polyHPMA-ellipticinium conjugates Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.bmc.2013.07.038
Description	Polymer conjugates of anticancer drugs have shown high potential for assisting in cancer treatments. The pH-labile spacers allow site-specific triggered release of the drugs. We synthesized and characterized model drug conjugates with hydrazide bond-containing poly[N-(2-hydroxypropyl)methacrylamide] differing in the chemical surrounding of the hydrazone bond-containing spacer to find structure-drug release rate relationships. The conjugate selected for further studies shows negligible drug release in a pH 7.4 buffer but released 50% of the ellipticinium drug within 24 h in a pH 5.0 phosphate saline buffer. The ellipticinium drug retained the antiproliferative activity of the ellipticine. Polymer conjugates of anticancer drugs have shown high potential for assisting in cancer treatments. The pH-labile spacers allow site-specific triggered release of the drugs. We synthesized and characterized model drug conjugates with hydrazide bond-containing poly[N-(2-hydroxypropyl)methacrylamide] differing in the chemical surrounding of the hydrazone bond-containing spacer to find structure-drug release rate relationships. The conjugate selected for further studies shows negligible drug release in a pH 7.4 buffer but released 50% of the ellipticinium drug within 24 h in a pH 5.0 phosphate saline buffer. The ellipticinium drug retained the antiproliferative activity of the ellipticine. (en)
Title	Fine tuning of the pH-dependent drug release rate from polyHPMA-ellipticinium conjugates Fine tuning of the pH-dependent drug release rate from polyHPMA-ellipticinium conjugates (en)
skos:prefLabel	Fine tuning of the pH-dependent drug release rate from polyHPMA-ellipticinium conjugates Fine tuning of the pH-dependent drug release rate from polyHPMA-ellipticinium conjugates (en)
skos:notation	RIV/00216208:11110/13:10192089!RIV14-GA0-11110___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(FR-TI4/625), P(GAP304/12/0950)
http://linked.open...iv/cisloPeriodika	18
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Větvička, David
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	75114
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/13:10192089
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Drug delivery; PolyHPMA; Hydrazone; Controlled release; Ellipticine (en)
http://linked.open.../riv/klicoveSlovo	Controlled release Ellipticine Hydrazone PolyHPMA Drug delivery
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[9D94545B3AA7]
http://linked.open...i/riv/nazevZdroje	Bioorganic and Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	New derivatives of 5-azacytosine nucleosides like demethylating therapeutics: identification of clinical candidates and efficiency biomarkers. Chelating polymers as therapeuticals for Wilson´s disease
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Hrubý, Martin Ulbrich, Karel Sedláček, Ondřej Větvička, David Studenovsky, Martin
http://linked.open...ain/vavai/riv/wos	000323803900002
issn	0968-0896
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bmc.2013.07.038
http://localhost/t...ganizacniJednotka	11110

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