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rdfs:seeAlso
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Description
| - These data identify JNK as a MAPK important for the activation of fibroblasts and for the synthesis of extracellular matrix in fibroblasts of SSc patients. The selective JNK-inhibitor CC930 disclosed potent anti-fibrotic effects in vitro as well as in different animal models of SSc. Supplementary, CC930 showed a physiological compatibility. Thus, JNK might be a potential novel molecular target for the treatment of fibrosis in SSc.
- These data identify JNK as a MAPK important for the activation of fibroblasts and for the synthesis of extracellular matrix in fibroblasts of SSc patients. The selective JNK-inhibitor CC930 disclosed potent anti-fibrotic effects in vitro as well as in different animal models of SSc. Supplementary, CC930 showed a physiological compatibility. Thus, JNK might be a potential novel molecular target for the treatment of fibrosis in SSc. (en)
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Title
| - Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis
- Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis (en)
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skos:prefLabel
| - Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis
- Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis (en)
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skos:notation
| - RIV/00216208:11110/12:12732!RIV13-MSM-11110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11110/12:12732
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - systemic sclerosis; experimental dermal fibrosis; JNK inhibitor; MAPK (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Annals of Rheumatic Diseases
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Akhmetshina, Alfiya
- Avouac, Jerome
- Beyer, Christian
- Dees, Clara
- Distler, Oliver
- Horn, Angelika
- Palumbo, Katrin
- Tomčík, Michal
- Zerr, Pawel
- Bennett, Brydon L.
- Distler, Joerg H. W.
- Lang, Veronika
- Reich, Nicole
- Schett, Georg
- Xie, Weilin
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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