About: Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis     Goto   Sponge   NotDistinct   Permalink

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Description
  • These data identify JNK as a MAPK important for the activation of fibroblasts and for the synthesis of extracellular matrix in fibroblasts of SSc patients. The selective JNK-inhibitor CC930 disclosed potent anti-fibrotic effects in vitro as well as in different animal models of SSc. Supplementary, CC930 showed a physiological compatibility. Thus, JNK might be a potential novel molecular target for the treatment of fibrosis in SSc.
  • These data identify JNK as a MAPK important for the activation of fibroblasts and for the synthesis of extracellular matrix in fibroblasts of SSc patients. The selective JNK-inhibitor CC930 disclosed potent anti-fibrotic effects in vitro as well as in different animal models of SSc. Supplementary, CC930 showed a physiological compatibility. Thus, JNK might be a potential novel molecular target for the treatment of fibrosis in SSc. (en)
Title
  • Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis
  • Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis (en)
skos:prefLabel
  • Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis
  • Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis (en)
skos:notation
  • RIV/00216208:11110/12:12732!RIV13-MSM-11110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 143962
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11110/12:12732
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • systemic sclerosis; experimental dermal fibrosis; JNK inhibitor; MAPK (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [26EA81FC9CA4]
http://linked.open...i/riv/nazevZdroje
  • Annals of Rheumatic Diseases
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 71
http://linked.open...iv/tvurceVysledku
  • Akhmetshina, Alfiya
  • Avouac, Jerome
  • Beyer, Christian
  • Dees, Clara
  • Distler, Oliver
  • Horn, Angelika
  • Palumbo, Katrin
  • Tomčík, Michal
  • Zerr, Pawel
  • Bennett, Brydon L.
  • Distler, Joerg H. W.
  • Lang, Veronika
  • Reich, Nicole
  • Schett, Georg
  • Xie, Weilin
http://linked.open...ain/vavai/riv/wos
  • 000302634000020
issn
  • 0003-4967
number of pages
http://localhost/t...ganizacniJednotka
  • 11110
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