About: Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis

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About: Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://onlinelibrary.wiley.com/doi/10.1002/art.34444/abstract;jsessionid=DF320B203BD50E01634E07F9FA6D183A.d03t02
Description	We demonstrated that the hedgehog pathway is activated in patients with SSc. Hedgehog signaling potently stimulates the release of collagen and myofibroblast differentiation in vitro and is sufficient to induce fibrosis in vivo. These findings identify the hedgehog cascade as a profibrotic pathway in SSc. We demonstrated that the hedgehog pathway is activated in patients with SSc. Hedgehog signaling potently stimulates the release of collagen and myofibroblast differentiation in vitro and is sufficient to induce fibrosis in vivo. These findings identify the hedgehog cascade as a profibrotic pathway in SSc. (en)
Title	Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis (en)
skos:prefLabel	Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis (en)
skos:notation	RIV/00216208:11110/12:12639!RIV13-MSM-11110___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Tomčík, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	138767
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/12:12639
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	systemic sclerosis; fibrosis; hedgehog signaling (en)
http://linked.open.../riv/klicoveSlovo	hedgehog signaling fibrosis systemic sclerosis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[11C7544F5D1E]
http://linked.open...i/riv/nazevZdroje	Arthritis & Rheumatism
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	16 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	64
http://linked.open...iv/tvurceVysledku	Akhmetshina, Alfiya Avouac, Jerome Dees, Clara Horn, Angelika Palumbo, Katrin Tomčík, Michal Zerr, Pawel Cordazzo, Cinzia Gusinde, Johannes Zwerina, Jochen
http://linked.open...ain/vavai/riv/wos	000306906500033
issn	0004-3591
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	11110

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