About: Limitations of Macroscopic Fluorescence Imaging for the Estimation of Tumour Growth in an Orthotopic Glioma Mouse Model

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About: Limitations of Macroscopic Fluorescence Imaging for the Estimation of Tumour Growth in an Orthotopic Glioma Mouse Model Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://fb.cuni.cz/file/5647/FB2012A0020.pdf
Description	Imaging methods based on light detection are being increasingly used for assesment of tumor growth in animal models. There are no studies assesing macroscopic FLI for monitoring of tumor growth in glioma mouse model. Human glioma cells expressing mKate2 were implanted to the brain of imunodeficient mouse. The tumor size was estimated by FLI and volume determined morphometrically. The fluorescent signal did not significantly correlate with the tumor volume. Therefore planar fluorescence imaging appearas to be suitable for semi-quantitative assesment of tumor growth rather then for precise volume estimation of xenografts located deep within the brain tissue. Imaging methods based on light detection are being increasingly used for assesment of tumor growth in animal models. There are no studies assesing macroscopic FLI for monitoring of tumor growth in glioma mouse model. Human glioma cells expressing mKate2 were implanted to the brain of imunodeficient mouse. The tumor size was estimated by FLI and volume determined morphometrically. The fluorescent signal did not significantly correlate with the tumor volume. Therefore planar fluorescence imaging appearas to be suitable for semi-quantitative assesment of tumor growth rather then for precise volume estimation of xenografts located deep within the brain tissue. (en)
Title	Limitations of Macroscopic Fluorescence Imaging for the Estimation of Tumour Growth in an Orthotopic Glioma Mouse Model Limitations of Macroscopic Fluorescence Imaging for the Estimation of Tumour Growth in an Orthotopic Glioma Mouse Model (en)
skos:prefLabel	Limitations of Macroscopic Fluorescence Imaging for the Estimation of Tumour Growth in an Orthotopic Glioma Mouse Model Limitations of Macroscopic Fluorescence Imaging for the Estimation of Tumour Growth in an Orthotopic Glioma Mouse Model (en)
skos:notation	RIV/00216208:11110/12:12125!RIV13-MSM-11110___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM0021620808)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Bušek, Petr Trylčová, Jana Hilšer, Marek Šedo, Aleksi
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	147081
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/12:12125
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	in vivo fluorescence imaging; mKate2; glioma growth (en)
http://linked.open.../riv/klicoveSlovo	glioma growth in vivo fluorescence imaging mKate2
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[B33807A91906]
http://linked.open...i/riv/nazevZdroje	Folia Biologica
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	58
http://linked.open...iv/tvurceVysledku	Bušek, Petr Šedo, Aleksi Hilšer, Marek Trylčová, Jana
http://linked.open...ain/vavai/riv/wos	000306098400006
http://linked.open...n/vavai/riv/zamer	Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu
issn	0015-5500
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	11110

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