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Description
  • We investigated the in vitro effects of amitriptyline, fluoxetine, tianeptine, ketamine, lithium, valproate, olanzapine, chlorpromazine and propranolol on mitochondrial respiration in crude mitochondrial fraction of pig brains. Antidepressants, but not mood stabilizers, ketamine and propranolol, were found to inhibit mitochondrial respiratory rate. Our findings suggest that mood stabilizers do not interfere with brain mitochondrial respiration, whereas direct mitochondrial targeting of psychopharmacologically different antidepressants is probably involved in their mechanisms of action.
  • We investigated the in vitro effects of amitriptyline, fluoxetine, tianeptine, ketamine, lithium, valproate, olanzapine, chlorpromazine and propranolol on mitochondrial respiration in crude mitochondrial fraction of pig brains. Antidepressants, but not mood stabilizers, ketamine and propranolol, were found to inhibit mitochondrial respiratory rate. Our findings suggest that mood stabilizers do not interfere with brain mitochondrial respiration, whereas direct mitochondrial targeting of psychopharmacologically different antidepressants is probably involved in their mechanisms of action. (en)
Title
  • In vitro inhibition of mitochondrial respiratory rate by antidepressants
  • In vitro inhibition of mitochondrial respiratory rate by antidepressants (en)
skos:prefLabel
  • In vitro inhibition of mitochondrial respiratory rate by antidepressants
  • In vitro inhibition of mitochondrial respiratory rate by antidepressants (en)
skos:notation
  • RIV/00216208:11110/12:11658!RIV13-MSM-11110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S, Z(MSM0021620849)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 141044
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11110/12:11658
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • antidepressant; mood stabilizer; mitochondria; respiratory rate (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • IE - Irsko
http://linked.open...ontrolniKodProRIV
  • [D6DC1016D651]
http://linked.open...i/riv/nazevZdroje
  • Toxicology Letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 213
http://linked.open...iv/tvurceVysledku
  • Fišar, Zdeněk
  • Hroudová, Jana
http://linked.open...ain/vavai/riv/wos
  • 000309170300006
http://linked.open...n/vavai/riv/zamer
issn
  • 0378-4274
number of pages
http://localhost/t...ganizacniJednotka
  • 11110
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