About: Nicotine and kainic acid effects on cortical epileptic afterdischarges in immature rats

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About: Nicotine and kainic acid effects on cortical epileptic afterdischarges in immature rats Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Aim of the study was to test the effect of nicotine (NIC) and kainic acid (KA) co-treatment in immature rats. Male Wistar albino rats (two different age groups) were chosen for the study. Experiments started on postnatal day (PD) 8 or 21 and animals were treated twice a day for three days with nicotine, fourth day KA was administered. Animals at PD12 (PD25 respectively) were examined electrophysiologically for cortical epileptic afterdischarges (ADs). First cortical ADs in PD12 animals were longer, when compared to PD25 rats (group treated with both substances). Nor NIC or KA treatment affected the length of discharges in PD12 rats. Older experimental group exhibited the shortening of the first ADs (group treated with NIC and KA, compared with groups exposed to single treatment). Few changes were found in KA treated group - 2(nd) and 4(th) ADs were shorter when compared with first ADs. These results demonstrate that NIC treatment played minor role in seizure susceptibility of PD12 rats, sensitivity to NIC differs during ontogenesis and subconvulsive dose of KA influenced the length of discharges only in PD25 animals. Aim of the study was to test the effect of nicotine (NIC) and kainic acid (KA) co-treatment in immature rats. Male Wistar albino rats (two different age groups) were chosen for the study. Experiments started on postnatal day (PD) 8 or 21 and animals were treated twice a day for three days with nicotine, fourth day KA was administered. Animals at PD12 (PD25 respectively) were examined electrophysiologically for cortical epileptic afterdischarges (ADs). First cortical ADs in PD12 animals were longer, when compared to PD25 rats (group treated with both substances). Nor NIC or KA treatment affected the length of discharges in PD12 rats. Older experimental group exhibited the shortening of the first ADs (group treated with NIC and KA, compared with groups exposed to single treatment). Few changes were found in KA treated group - 2(nd) and 4(th) ADs were shorter when compared with first ADs. These results demonstrate that NIC treatment played minor role in seizure susceptibility of PD12 rats, sensitivity to NIC differs during ontogenesis and subconvulsive dose of KA influenced the length of discharges only in PD25 animals. (en)
Title	Nicotine and kainic acid effects on cortical epileptic afterdischarges in immature rats Nicotine and kainic acid effects on cortical epileptic afterdischarges in immature rats (en)
skos:prefLabel	Nicotine and kainic acid effects on cortical epileptic afterdischarges in immature rats Nicotine and kainic acid effects on cortical epileptic afterdischarges in immature rats (en)
skos:notation	RIV/00216208:11110/12:11480!RIV13-GA0-11110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GP305/09/P136)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Riljak, Vladimír Marešová, Dana Pokorný, Jaroslav Jandová, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	154225
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/12:11480
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	evoked potentials; afterdischarges; nicotine; kainic acid; rat (en)
http://linked.open.../riv/klicoveSlovo	nicotine evoked potentials rat kainic acid afterdischarges
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[A935BFD273AD]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Nicotine as a protective agent in neurodegenerative disorders - an ontogenetic study
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	61
http://linked.open...iv/tvurceVysledku	Pokorný, Jaroslav Marešová, Dana Riljak, Vladimír Jandová, Kateřina
http://linked.open...ain/vavai/riv/wos	000313862700012
issn	0862-8408
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	11110

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