About: Impact of chronic ethanol intake of rat mothers on the seizure susceptibility of their immature male offspring

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About: Impact of chronic ethanol intake of rat mothers on the seizure susceptibility of their immature male offspring Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.4149/gpb_2012_019
Description	The aim of present study was to examine the impact of prenatal ethanol exposure on seizure susceptibility of the offspring. Pregnant Wistar rats were compelled to drink either 10% or 20% ethanol solution, as the only drinking fluid since conception up to the weaning of their offspring at the age of 28 days. Pregnant and nursing rats of the control group drank water. Electrophysiological experiments (repeated electrical stimulation and analysis of cortical afterdischarges duration) were than performed on their immature offspring. Rat pups were tested on postnatal day 18, 25, and 35. Shortening of afterdischarges duration was observed in 18-day-old animals (mothers drank 20% ethanol) when compared with age matched controls and failure of post-ictal depression phenomenon was found in 25- and 35-day-old animals. Our findings signalize that ethanol exposure during pregnancy influences seizure susceptibility by acting on excitatory/inhibitory brain systems and this effect is dose- and age-dependent. The aim of present study was to examine the impact of prenatal ethanol exposure on seizure susceptibility of the offspring. Pregnant Wistar rats were compelled to drink either 10% or 20% ethanol solution, as the only drinking fluid since conception up to the weaning of their offspring at the age of 28 days. Pregnant and nursing rats of the control group drank water. Electrophysiological experiments (repeated electrical stimulation and analysis of cortical afterdischarges duration) were than performed on their immature offspring. Rat pups were tested on postnatal day 18, 25, and 35. Shortening of afterdischarges duration was observed in 18-day-old animals (mothers drank 20% ethanol) when compared with age matched controls and failure of post-ictal depression phenomenon was found in 25- and 35-day-old animals. Our findings signalize that ethanol exposure during pregnancy influences seizure susceptibility by acting on excitatory/inhibitory brain systems and this effect is dose- and age-dependent. (en)
Title	Impact of chronic ethanol intake of rat mothers on the seizure susceptibility of their immature male offspring Impact of chronic ethanol intake of rat mothers on the seizure susceptibility of their immature male offspring (en)
skos:prefLabel	Impact of chronic ethanol intake of rat mothers on the seizure susceptibility of their immature male offspring Impact of chronic ethanol intake of rat mothers on the seizure susceptibility of their immature male offspring (en)
skos:notation	RIV/00216208:11110/12:11470!RIV13-GA0-11110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GP305/09/P136)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Riljak, Vladimír Marešová, Dana Pokorný, Jaroslav Jandová, Kateřina Bortelová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	140583
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/12:11470
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Ethanol; Evoked potentials; Seizure; Development; Rat; prenatal alcohol exposure; epileptic afterdischarges; somatosensory cortex; hypoxia; neurons; suppresses; gaba (en)
http://linked.open.../riv/klicoveSlovo	somatosensory cortex hypoxia epileptic afterdischarges Development Ethanol Rat Evoked potentials Seizure gaba prenatal alcohol exposure suppresses neurons
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[F8498AF550DE]
http://linked.open...i/riv/nazevZdroje	General Physiology and Biophysics
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Nicotine as a protective agent in neurodegenerative disorders - an ontogenetic study
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Pokorný, Jaroslav Marešová, Dana Riljak, Vladimír Jandová, Kateřina Bortelová, Jana
http://linked.open...ain/vavai/riv/wos	000305315600006
issn	0231-5882
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	11110

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